Cisplatin is an effective chemotherapeutic agent for various solid tumours, but its use is
limited by adverse effects in normal tissues. In particular, cisplatin is nephrotoxic and can …

Cisplatin and other platinum derivatives are the most widely used chemotherapeutic agents
to treat solid tumors including ovarian, head and neck, and testicular germ cell tumors. A …

Resveratrol induces mitochondrial biogenesis and protects against metabolic decline, but
whether SIRT1 mediates these benefits is the subject of debate. To circumvent the …

Resveratrol is a pleiotropic phytochemical belonging to the stilbene family. Though it is only
significantly present in grape products, a huge amount of preclinical studies investigated its …

Sirtuins (SIRT), first discovered in yeast as NAD+ dependent epigenetic and metabolic
regulators, have comparable activities in human physiology and disease. Mounting …

Sirtuins or Sir2 family of proteins are a class of NAD+ dependent protein deacetylases which
are evolutionarily conserved from bacteria to humans. Some sirtuins also exhibit mono-ADP …

Although the increased lifespan of our populations illustrates the success of modern
medicine, the risk of developing many diseases increases exponentially with old age …

Cisplatin is one of the most widely used and highly effective drug for the treatment of various
solid tumors; however, it has dose-dependent side effects on the kidney, cochlear, and …

Sirtuin 1 (SIRT1), the mammalian Sir2 homologue, is a class III histone deacetylase shown
to act on a wide range of histones and non-histone substrates. Numerous studies have …

Acetaminophen (APAP) is a widely used analgesic and antipyretic over-the-counter
medicine worldwide. Hepatotoxicity caused by APAP overdose is one of the leading causes …