Freedom to err: The expanding cellular functions of translesion DNA polymerases
I Paniagua, JJL Jacobs - Molecular Cell, 2023 - cell.com
Translesion synthesis (TLS) DNA polymerases were originally described as error-prone
enzymes involved in the bypass of DNA lesions. However, extensive research over the past …
enzymes involved in the bypass of DNA lesions. However, extensive research over the past …
Polymerase η recruits DHX9 helicase to promote replication across guanine quadruplex structures
DNA polymerase η (Pol η) catalyzes accurate bypass of ultraviolet light-induced cyclobutane
pyrimidine dimers, and it also functions in several other related processes, including …
pyrimidine dimers, and it also functions in several other related processes, including …
Layer-by-layer assembled magnetic molecularly imprinted nanoparticles for highly specific separation of adenosine 5′-monophosphate: Relations between …
W Wang, H Li, M Li, H Lu, J Pan - Separation and Purification Technology, 2024 - Elsevier
Molecularly imprinted polymers (MIPs) are an effective method to accurately recognize and
isolate targets. Adenosine 5′-monophosphate (AMPs) are typical nucleoside compounds …
isolate targets. Adenosine 5′-monophosphate (AMPs) are typical nucleoside compounds …
HMGB3 and SUB1 Bind to and Facilitate the Repair of N2-Alkylguanine Lesions in DNA
N 2-Alkyl-2′-deoxyguanosine (N 2-alkyl-dG) is a major type of minor-groove DNA lesions
arising from endogenous metabolic processes and exogenous exposure to environmental …
arising from endogenous metabolic processes and exogenous exposure to environmental …
Activity of DNA polymerase κ across the genome in human fibroblasts
MC Torres, A Rebok, D Sun, TE Spratt - Proceedings of the National …, 2024 - pnas.org
DNA polymerase κ (Polκ) is a specialized polymerase that has multiple cellular roles such
as translesion DNA synthesis, replication of repetitive sequences, and nucleotide excision …
as translesion DNA synthesis, replication of repetitive sequences, and nucleotide excision …
Mass spectrometry-based assays for assessing replicative bypass and repair of DNA alkylation in cells
J Li, Z Hu, D Liu, P Wang - RSC advances, 2023 - pubs.rsc.org
Endogenous metabolism and environmental exposure can give rise to DNA alkylation,
which can elicit deleterious biological consequences. In the search for reliable and …
which can elicit deleterious biological consequences. In the search for reliable and …
LC-MS/MS for Assessing the Incorporation and Repair of N2-Alkyl-2′-deoxyguanosine in Genomic DNA
Understanding the occurrence, repair, and biological consequences of DNA damage is
important in environmental toxicology and risk assessment. The most common way to …
important in environmental toxicology and risk assessment. The most common way to …
DNA Replication across α-l-(3′-2′)-Threofuranosyl Nucleotides Mediated by Human DNA Polymerase η
α-l-(3′-2′)-Threofuranosyl nucleic acid (TNA) pairs with itself, cross-pairs with DNA and
RNA, and shows promise as a tool in synthetic genetics, diagnostics, and oligonucleotide …
RNA, and shows promise as a tool in synthetic genetics, diagnostics, and oligonucleotide …
DNA polymerase κ participates in early S-phase DNA replication in human cells
Cycling cells replicate their DNA during the S phase through a defined temporal program
known as replication timing. Mutation frequencies, epigenetic chromatin states, and …
known as replication timing. Mutation frequencies, epigenetic chromatin states, and …
Size-and stereochemistry-dependent transcriptional bypass of DNA alkyl phosphotriester adducts in mammalian cells
Environmental, endogenous and therapeutic alkylating agents can react with internucleotide
phosphate groups in DNA to yield alkyl phosphotriester (PTE) adducts. Alkyl-PTEs are …
phosphate groups in DNA to yield alkyl phosphotriester (PTE) adducts. Alkyl-PTEs are …