Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies

X Wu, M Xu, M Geng, S Chen, PJ Little, S Xu… - Signal transduction and …, 2023 - nature.com
The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major
public health burden worldwide. The most common form of NCD is metabolic diseases …

The interplay among oxidative stress, brain insulin resistance and AMPK dysfunction contribute to neurodegeneration in type 2 diabetes and Alzheimer disease

E Barone, F Di Domenico, M Perluigi… - Free Radical Biology and …, 2021 - Elsevier
Alzheimer's disease (AD) is the most common form of dementia in the elderly followed by
vascular dementia. In addition to clinically diagnosed dementia, cognitive dysfunction has …

[HTML][HTML] Aberrant protein s-nitrosylation in neurodegenerative diseases

T Nakamura, S Tu, MW Akhtar, CR Sunico, S Okamoto… - Neuron, 2013 - cell.com
S-Nitrosylation is a redox-mediated posttranslational modification that regulates protein
function via covalent reaction of nitric oxide (NO)-related species with a cysteine thiol group …

NO donors as the wonder molecules with therapeutic potential: Recent trends and future perspectives

GR Navale, S Singh, K Ghosh - Coordination Chemistry Reviews, 2023 - Elsevier
Nitric oxide (NO), an endogenous, free radical, highly unstable, diatomic gaseous molecule,
plays crucial roles in several physiological and pathological processes. It has attracted …

[HTML][HTML] The role of nitric oxide in brain disorders: Autism spectrum disorder and other psychiatric, neurological, and neurodegenerative disorders

MK Tripathi, M Kartawy, H Amal - Redox Biology, 2020 - Elsevier
Nitric oxide (NO) is a multifunctional signalling molecule and a neurotransmitter that plays
an important role in physiological and pathophysiological processes. In physiological …

Alzheimer's disease: pathological mechanisms and the beneficial role of melatonin

SA Rosales‐Corral, D Acuña‐Castroviejo… - Journal of pineal …, 2012 - Wiley Online Library
Alzheimer's disease (AD) is a highly complex neurodegenerative disorder of the aged that
has multiple factors which contribute to its etiology in terms of initiation and progression. This …

[PDF][PDF] Nitric oxide—the endothelium-derived relaxing factor and its role in endothelial functions

V Bauer, R Sotníková - General physiology and biophysics, 2010 - researchgate.net
Vascular endothelium plays a key role in the local regulation of vascular tone and vascular
architecture by release of vasodilator and vasoconstrictor substances, as well as factors with …

Insulin as an immunomodulatory hormone

G Van Niekerk, C Christowitz, D Conradie… - Cytokine & growth factor …, 2020 - Elsevier
Insulin plays an indispensable role in the management of hyperglycaemia that arises in a
variety of settings, including Type I and II diabetes, gestational diabetes, as well as is in …

Modulation of insulin sensitivity by insulin-degrading enzyme

CM González-Casimiro, B Merino… - Biomedicines, 2021 - mdpi.com
Insulin-degrading enzyme (IDE) is a highly conserved and ubiquitously expressed
metalloprotease that degrades insulin and several other intermediate-size peptides. For …

Regulation of vascular tone homeostasis by NO and H2S: Implications in hypertension

S Gheibi, S Jeddi, K Kashfi, A Ghasemi - Biochemical pharmacology, 2018 - Elsevier
Nitric oxide (NO) and hydrogen sulfide (H 2 S) are two gasotransmitters that are produced in
the vasculature and contribute to the regulation of vascular tone. NO and H 2 S are …