Recent studies have shown that the respiratory system has an extensive ability to respond to
injury and regenerate lost or damaged cells. The unperturbed adult lung is remarkably …

Macrophages derived from human induced pluripotent stem cells (iPSCs) have the potential
to enable the development of cell-based therapies for numerous disease conditions. We …

Bone-marrow transplantation is an effective cell therapy but requires myeloablation, which
increases infection risk and mortality. Recent lineage-tracing studies documenting that …

Tractable and accurate disease models are essential for understanding disease
pathogenesis and for developing new therapeutics. As stem cells are capable of self …

The constant supply of high cell numbers generated by defined, robust, and economically
viable culture processes is indispensable for the envisioned application of human …

Summary Interleukin-3 (IL-3) is capable of supporting the proliferation of a broad range of
hematopoietic cell types, whereas granulocyte colony-stimulating factor (G-CSF) and …

Pulmonary alveolar proteinosis (PAP) is a diffuse lung disease that results from the
accumulation of lipoproteinaceous material in the alveoli and alveolar macrophages due to …

The increasing number of severe infections with multi-drug-resistant pathogens worldwide
highlights the need for alternative treatment options. Given the pivotal role of phagocytes …

Advances in physiology and biochemistry have provided fundamental insights into the role
of pulmonary surfactant in the pathogenesis and treatment of preterm infants with respiratory …

Pulmonary alveolar proteinosis (PAP) is a syndrome characterized by the accumulation of
alveolar surfactant and dysfunction of alveolar macrophages. PAP results in progressive …