ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries
This review summarizes the last decade of work by the ENIGMA (E nhancing N euro I
maging G enetics through M eta A nalysis) Consortium, a global alliance of over 1400 …
maging G enetics through M eta A nalysis) Consortium, a global alliance of over 1400 …
The polygenic architecture of schizophrenia—rethinking pathogenesis and nosology
Schizophrenia is a severe psychiatric disorder with considerable morbidity and mortality.
Although the past two decades have seen limited improvement in the treatment of …
Although the past two decades have seen limited improvement in the treatment of …
Therapeutic potential of TAAR1 agonists in schizophrenia: evidence from preclinical models and clinical studies
Trace amine-associated receptor 1 (TAAR1) has emerged as a promising therapeutic target
for neuropsychiatric disorders due to its ability to modulate monoaminergic and …
for neuropsychiatric disorders due to its ability to modulate monoaminergic and …
[HTML][HTML] The dual hit hypothesis of schizophrenia: Evidence from animal models
Schizophrenia is a heterogeneous psychiatric disorder, which can severely impact social
and professional functioning. Epidemiological and clinical studies show that schizophrenia …
and professional functioning. Epidemiological and clinical studies show that schizophrenia …
Overlapping and specific neural correlates for empathizing, affective mentalizing, and cognitive mentalizing: A coordinate‐based meta‐analytic study
While the discussion on the foundations of social understanding mainly revolves around the
notions of empathy, affective mentalizing, and cognitive mentalizing, their degree of overlap …
notions of empathy, affective mentalizing, and cognitive mentalizing, their degree of overlap …
Epigenetic modifications in schizophrenia and related disorders: molecular scars of environmental exposures and source of phenotypic variability
J Richetto, U Meyer - Biological Psychiatry, 2021 - Elsevier
Epigenetic modifications are increasingly recognized to play a role in the etiology and
pathophysiology of schizophrenia and other psychiatric disorders with developmental …
pathophysiology of schizophrenia and other psychiatric disorders with developmental …
Cross disorder comparisons of brain structure in schizophrenia, bipolar disorder, major depressive disorder, and 22q11. 2 deletion syndrome: a review of ENIGMA …
This review compares the main brain abnormalities in schizophrenia (SZ), bipolar disorder
(BD), major depressive disorder (MDD), and 22q11. 2 Deletion Syndrome (22q11DS) …
(BD), major depressive disorder (MDD), and 22q11. 2 Deletion Syndrome (22q11DS) …
[HTML][HTML] Going deep into schizophrenia with artificial intelligence
Despite years of research, the mechanisms governing the onset, relapse, symptomatology,
and treatment of schizophrenia (SZ) remain elusive. The lack of appropriate analytic tools to …
and treatment of schizophrenia (SZ) remain elusive. The lack of appropriate analytic tools to …
Individual deviations from normative models of brain structure in a large cross-sectional schizophrenia cohort
The heterogeneity of schizophrenia has defied efforts to derive reproducible and definitive
anatomical maps of structural brain changes associated with the disorder. We aimed to map …
anatomical maps of structural brain changes associated with the disorder. We aimed to map …
Perturbed iron biology in the prefrontal cortex of people with schizophrenia
Despite loss of grey matter volume and emergence of distinct cognitive deficits in young
adults diagnosed with schizophrenia, current treatments for schizophrenia do not target …
adults diagnosed with schizophrenia, current treatments for schizophrenia do not target …