Monoclonal antibody-based immunotherapy is now considered to be a main component of
cancer therapy, alongside surgery, radiation, and chemotherapy. Monoclonal antibodies …

The biggest hurdle to targeted cancer therapy is the inevitable emergence of drug
resistance. Tumor cells employ different mechanisms to resist the targeting agent. Most …

Oral squamous cell carcinoma (OSCC) is the most common malignancy representing 90%
of all forms of oral cancer worldwide. Although great efforts have been made in the past …

Background Aberrant changes in epigenetic mechanisms such as histone modifications play
an important role in cancer progression. PRMT1 which triggers asymmetric dimethylation of …

Epithelial–mesenchymal transition (EMT) is a pivotal mechanism for cancer dissemination.
However, EMT-regulated individual cancer cell invasion is difficult to detect in clinical …

Resistance to treatment is one of the biggest challenges in combating head and neck
squamous cell carcinoma (HNSCC). The concept of resistance, however, is often viewed as …

Oral squamous cell carcinoma (SCC) is a prevalent malignant disease worldwide,
especially so in Taiwan. Early-or even preclinical-stage detection is critical for reducing …

Although aberrant EGFR signaling is widespread in cancer, EGFR inhibition is effective only
in a subset of non–small cell lung cancer (NSCLC) with EGFR activating mutations. A …

Head and neck squamous cell carcinoma (HNSCC) is the sixth most incident cancer
worldwide. More than half of HNSCC patients experience locoregional or distant relapse to …

Prospective tumor pH-responsive and charge-convertible nanoparticles have been utilized
to reduce side effects and improve the active tumor-targeting ability and nuclear/cytoplasmic …