Respiration is a brain function on which our lives essentially depend. Control of respiration
ensures that the frequency and depth of breathing adapt continuously to metabolic needs. In …

Breathing is a well-described, vital and surprisingly complex behaviour, with behavioural
and physiological outputs that are easy to directly measure. Key neural elements for …

Breathing is a vital rhythmic motor behavior with a surprisingly broad influence on the brain
and body. The apparent simplicity of breathing belies a complex neural control system, the …

The preBötzinger Complex (preBötC), a medullary network critical for breathing, relies on
excitatory interneurons to generate the inspiratory rhythm. Yet, half of preBötC neurons are …

The circuit organization within the mammalian brainstem respiratory network, specifically
within and between the pre-Bötzinger (pre-BötC) and Bötzinger (BötC) complexes, and the …

Twenty‐five years ago, a new physiological preparation called the working heart–brainstem
preparation (WHBP) was introduced with the claim it would provide a new platform allowing …

Breathing is vital for survival but also interesting from the perspective of rhythm generation.
This rhythmic behavior is generated within the brainstem and is thought to emerge through …

Breathing's remarkable ability to adapt to changes in metabolic, environmental, and
behavioral demands stems from a complex integration of its rhythm-generating network …

Rhythmicity is a universal timing mechanism in the brain, and the rhythmogenic mechanisms
are generally dynamic. This is illustrated for the neuronal control of breathing, a behavior …

Opioids depress minute ventilation primarily by reducing respiratory rate. This results from
direct effects on the preBötzinger Complex as well as from depression of the …