The Hippo pathway remains a central focus in both basic and translational research and is a
key modulator of developmental biology. Dysregulation of the pathway is associated with a …

Simple Summary Although great breakthroughs have been made in cancer treatment
following the development of targeted therapy and immune therapy, resistance against anti …

Taxol (paclitaxel) resistance represents a major challenge in breast cancer treatment. The
TAZ (t ranscriptional co-a ctivator with PD Z-binding motif) oncogene is a major component …

Cancer metastasis refers to the sequence of events whereby tumour cells detach from their
primary tissue, invade and migrate to nearby vasculature, intravasate into circulation, survive …

Since cancer is one of the leading causes of death worldwide, there is an urgent need to find
better treatments. Currently, the use of chemotherapeutics remains the predominant option …

The large tumor suppressor 1 (LATS1) is a serine/threonine kinase and tumor suppressor
found down-regulated in a broad spectrum of human cancers. LATS1 is a central player of …

Growing evidence suggests that YAP/TAZ are mediators of the Hippo pathway and promote
breast cancer. However, the roles of YAP/TAZ transcription factor partners TEADs in breast …

Although antitubulin drugs are used widely to treat human cancer, many patients display
intrinsic or acquired drug resistance that imposes major obstacles to successful therapy …

Chemotherapy is one of the major treatments for cancer patients. Although
chemotherapeutic drugs can sometimes effectively suppress tumor growth in cancer …

The MST/Hippo signalling pathway was first described over a decade ago in Drosophila
melanogaster and the core of the pathway is evolutionary conserved in mammals. The …