Autophagy, as a type II programmed cell death, plays crucial roles with autophagy-related
(ATG) proteins in cancer. Up to now, the dual role of autophagy both in cancer progression …

Autophagosomes are double-membrane vesicles newly formed during autophagy to engulf
a wide range of intracellular material and transport this autophagic cargo to lysosomes (or …

Autophagy is the process of cellular self-eating by a double-membrane organelle, the
autophagosome. A range of signaling processes converge on two protein complexes to …

Selective autophagy is a quality control pathway through which cellular components are
sequestered into double-membrane vesicles and delivered to specific intracellular …

Autophagosome biogenesis is a dynamic membrane event, which is executed by the
sequential function of autophagy-related (ATG) proteins. Upon autophagy induction, a cup …

A GGGGCC hexanucleotide repeat expansion in the C9orf72 gene is the most common
genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia (C9 ALS/FTD) …

Autophagy has burgeoned rapidly as a field of study because of its evolutionary
conservation, the diversity of intracellular cargoes degraded and recycled by this machinery …

Eukaryotic cells adequately control the mass and functions of organelles in various
situations. Autophagy, an intracellular degradation system, largely contributes to this …

Autophagosome formation requires sequential translocation of autophagy-specific proteins
to membranes enriched in PI3P and connected to the ER. Preceding this, the earliest …

Bilayered phospholipid membranes are vital to the organization of the living cell. Based on
fundamental principles of polarity, membranes create borders allowing defined spaces to be …