Amino assets: how amino acids support immunity
Amino acids are fundamental building blocks supporting life. Their role in protein synthesis
is well defined, but they contribute to a host of other intracellular metabolic pathways …
is well defined, but they contribute to a host of other intracellular metabolic pathways …
Understanding subset diversity in T cell memory
SC Jameson, D Masopust - Immunity, 2018 - cell.com
Considerable advances have been made in recent years in understanding the generation
and function of memory T cells. Memory T cells are typically parsed into discreet subsets …
and function of memory T cells. Memory T cells are typically parsed into discreet subsets …
Effector CD8 T cells dedifferentiate into long-lived memory cells
Memory CD8 T cells that circulate in the blood and are present in lymphoid organs are an
essential component of long-lived T cell immunity. These memory CD8 T cells remain …
essential component of long-lived T cell immunity. These memory CD8 T cells remain …
Heterogenous populations of tissue-resident CD8+ T cells are generated in response to infection and malignancy
Tissue-resident memory CD8+ T cells (Trm) provide host protection through continuous
surveillance of non-lymphoid tissues. Using single-cell RNA-sequencing (scRNA-seq) and …
surveillance of non-lymphoid tissues. Using single-cell RNA-sequencing (scRNA-seq) and …
CD4 + T-cell subsets in inflammatory diseases: beyond the T h 1/T h 2 paradigm
K Hirahara, T Nakayama - International immunology, 2016 - academic.oup.com
CD4+ T cells are crucial for directing appropriate immune responses during host defense
and for the pathogenesis of inflammatory diseases. In addition to the classical biphasic …
and for the pathogenesis of inflammatory diseases. In addition to the classical biphasic …
Cytomegalovirus infection drives adaptive epigenetic diversification of NK cells with altered signaling and effector function
The mechanisms underlying human natural killer (NK) cell phenotypic and functional
heterogeneity are unknown. Here, we describe the emergence of diverse subsets of human …
heterogeneity are unknown. Here, we describe the emergence of diverse subsets of human …
Molecular regulation of effector and memory T cell differentiation
JT Chang, EJ Wherry, AW Goldrath - Nature immunology, 2014 - nature.com
Immunological memory is a cardinal feature of adaptive immunity and an important goal of
vaccination strategies. Here we highlight advances in the understanding of the diverse T …
vaccination strategies. Here we highlight advances in the understanding of the diverse T …
S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate
R-2-hydroxyglutarate accumulates to millimolar levels in cancer cells with gain-of-function
isocitrate dehydrogenase 1/2 mutations. These levels of R-2-hydroxyglutarate affect 2 …
isocitrate dehydrogenase 1/2 mutations. These levels of R-2-hydroxyglutarate affect 2 …
Heterogeneity and clonal relationships of adaptive immune cells in ulcerative colitis revealed by single-cell analyses
Inflammatory bowel disease (IBD) encompasses a spectrum of gastrointestinal disorders
driven by dysregulated immune responses against gut microbiota. We integrated single-cell …
driven by dysregulated immune responses against gut microbiota. We integrated single-cell …
Early precursors and molecular determinants of tissue-resident memory CD8+ T lymphocytes revealed by single-cell RNA sequencing
During an immune response to microbial infection, CD8+ T cells give rise to distinct classes
of cellular progeny that coordinately mediate clearance of the pathogen and provide long …
of cellular progeny that coordinately mediate clearance of the pathogen and provide long …