Macroautophagy/autophagy is a cellular catabolic process that results in lysosome-
mediated recycling of organelles and protein aggregates, as well as the destruction of …

Standard follow-up and symptomatic treatment have allowed most patients with cystic
fibrosis to live to young adulthood. However, many patients still die prematurely from …

Autophagy, once viewed exclusively as a cytoplasmic auto-digestive process, has its less
intuitive but biologically distinct non-degradative roles. One manifestation of these functions …

Advances over the past 25 years have revealed much about how the structural properties of
membranes and associated proteins are linked to the thermodynamics and kinetics of …

Age-related declines in cognitive fitness are associated with a reduction in autophagy, an
intracellular lysosomal catabolic process that regulates protein homeostasis and organelle …

Cigarette-smoke (CS) exposure and aging are the leading causes of chronic obstructive
pulmonary disease (COPD)-emphysema development, although the molecular mechanism …

Cystic fibrosis (CF), a monogenic disease caused by mutations in the CFTR gene on
chromosome 7, is complex and greatly variable in clinical expression. Airways, pancreas …

Cystic fibrosis (CF) is the most common life-threatening monogenic disease afflicting
Caucasian people. It affects the respiratory, gastrointestinal, glandular and reproductive …

Autophagy (“self-eating”) constitutes one of the most spectacular yet subtly regulated
phenomena in cell biology. Similarly to cell division, differentiation, and death, autophagy is …

Cellular signaling pathways involved in the maintenance of the equilibrium between cell
proliferation and apoptosis have emerged as rational targets that can be exploited in the …