Doxorubicin (DOX) is one of the most widely used and successful antitumor drugs, but its
cumulative and dose-dependent cardiac toxicity has been a major concern of oncologists in …

The heart has complex mechanisms that facilitate the maintenance of an oxygen supply–
demand balance necessary for its contractile function in response to physiological …

Reactive oxygen species (ROS) are subcellular messengers in gene regulatory and signal
transduction pathways. In pathological situations, ROS accumulate due to excessive …

Reactive oxygen species (ROS) contribute to several aspects of vascular diseases including
ischemia–reperfusion injury, scavenging of nitric oxide, or stimulation of inflammation and …

The multifunctional Ca2+-and calmodulin-dependent protein kinase II (CaMKII) is now
recognized to play a central role in pathological events in the cardiovascular system. CaMKII …

Significance: Oxidative stress is involved in the pathogenesis of heart failure but clinical
antioxidant trials have been unsuccessful. This may be because effects of reactive oxygen …

Oxidative stress, an alteration in the balance between reactive oxygen species (ROS)
generation and antioxidant buffering capacity, has been implicated in the pathogenesis of …

Key points• Ageing is associated with increased risk of sudden cardiac death due to
malignant arrhythmias.• Shortened refractoriness of Ca2+ release due to increased activity …

Reactive oxygen species (ROS) plays a role in intracellular signal transduction under
physiological conditions while also playing an essential role in diseases such as …

Endothelin-1 (ET-1) is a multifunctional hormone which regulates the physiology of the
cardiovascular and renal systems. ET-1 modulates cardiac contractility, systemic and renal …