Large-conductance Ca2+-and voltage-activated K+ (BK) channels play many physiological
roles ranging from the maintenance of smooth muscle tone to hearing and neurosecretion …

Novel KCNMA1 variants, encoding the BK K+ channel, are associated with a debilitating
dyskinesia and epilepsy syndrome. Neurodevelopmental delay, cognitive disability, and …

Insecticides are indispensable tools for plant protection in modern agriculture. Despite
having highly heterogeneous structures, many neurotoxic insecticides use similar principles …

Abstract High-conductance,'big'potassium (BK) channels encoded by the Slo gene family
are among the largest and most complex of the extended family of potassium channels. The …

C. elegans feeding depends on the action of the pharynx, a neuromuscular pump that joins
the mouth to the intestine. The pharyngeal muscle captures food—bacteria—and transports …

Neurons in Caenorhabditis elegans and other nematodes have been thought to lack
classical action potentials. Unexpectedly, we observe membrane potential spikes with …

The activities of many neuronal proteins are modulated by ethanol, but the fundamental
mechanisms underlying behavioral effects of ethanol remain unclear. To identify …

The large-conductance, calcium-activated potassium channels (BK, also termed BKCa, Slo,
or MaxiK) distributed in both excitable and non-excitable cells are involved in many cellular …

Background Caenorhabditis elegans locomotion is a simple behavior that has been widely
used to dissect genetic components of behavior, synaptic transmission, and muscle function …

Caenorhabditis elegans has emerged as a powerful model system for studying the biology
of the synapse. Here we describe a widely used assay for synaptic transmission at the C …