Human platelet lysate: replacing fetal bovine serum as a gold standard for human cell propagation?

T Burnouf, D Strunk, MBC Koh, K Schallmoser - Biomaterials, 2016 - Elsevier
The essential physiological role of platelets in wound healing and tissue repair builds the
rationale for the use of human platelet derivatives in regenerative medicine. Abundant …

Scaled preparation of extracellular vesicles from conditioned media

S Staubach, FN Bauer, T Tertel, V Börger… - Advanced drug delivery …, 2021 - Elsevier
Extracellular vesicles (EVs) especially of mesenchymal stem/stomal cells (MSCs) are
increasingly considered as biotherapeutic agents for a variety of different diseases. For …

A functional corona around extracellular vesicles enhances angiogenesis, skin regeneration and immunomodulation

M Wolf, RW Poupardin, P Ebner‐Peking… - Journal of …, 2022 - Wiley Online Library
Nanoparticles can acquire a plasma protein corona defining their biological identity. Corona
functions were previously considered for cell‐derived extracellular vesicles (EVs). Here we …

Applying extracellular vesicles based therapeutics in clinical trials–an ISEV position paper

T Lener, M Gimona, L Aigner, V Börger… - Journal of …, 2015 - Taylor & Francis
Extracellular vesicles (EVs), such as exosomes and microvesicles, are released by different
cell types and participate in physiological and pathophysiological processes. EVs mediate …

Critical reevaluation of endothelial progenitor cell phenotypes for therapeutic and diagnostic use

GP Fadini, D Losordo, S Dimmeler - Circulation research, 2012 - Am Heart Assoc
Diverse subsets of endothelial progenitor cells (EPCs) are used for the treatment of ischemic
diseases in clinical trials, and circulating EPCs levels are considered as biomarkers for …

Reciprocal leukemia-stroma VCAM-1/VLA-4-dependent activation of NF-κB mediates chemoresistance

R Jacamo, Y Chen, Z Wang, W Ma… - Blood, The Journal …, 2014 - ashpublications.org
Leukemia cells are protected from chemotherapy-induced apoptosis by their interactions
with bone marrow mesenchymal stromal cells (BM-MSCs). Yet the underlying mechanisms …

Patterning human stem cells and endothelial cells with laser printing for cardiac regeneration

R Gaebel, N Ma, J Liu, J Guan, L Koch, C Klopsch… - Biomaterials, 2011 - Elsevier
Recent study showed that mesenchymal stem cells (MSC) could inhibit apoptosis of
endothelial cells in hypoxic condition, increase their survival, and stimulate the …

Mesenchymal stem and progenitor cells in regeneration: tissue specificity and regenerative potential

R Rohban, TR Pieber - Stem cells international, 2017 - Wiley Online Library
It has always been an ambitious goal in medicine to repair or replace morbid tissues for
regaining the organ functionality. This challenge has recently gained momentum through …

Steroid-induced osteonecrosis of the femoral head: novel insight into the roles of bone endothelial cells in pathogenesis and treatment

C Huang, Z Wen, J Niu, S Lin, W Wang - Frontiers in cell and …, 2021 - frontiersin.org
Steroid-induced osteonecrosis of the femoral head (SONFH) is a disease characterized by
the collapse of the femoral head. SONFH occurs due to the overuse of glucocorticoids (GCs) …

Concise review: endothelial progenitor cells in regenerative medicine: applications and challenges

MSK Chong, WK Ng, JKY Chan - Stem cells translational …, 2016 - academic.oup.com
Endothelial progenitor cells (EPCs) are currently being studied as candidate cell sources for
revascularization strategies. Significant advances have been made in understanding the …