[HTML][HTML] Exosomes derived from mesenchymal stem cells

B Yu, X Zhang, X Li - International journal of molecular sciences, 2014 - mdpi.com
The functional mechanisms of mesenchymal stem cells (MSCs) have become a research
focus in recent years. Accumulating evidence supports the notion that MSCs act in a …

[HTML][HTML] Mesenchymal stem cell treatment for COVID-19

R Xu, Z Feng, FS Wang - EBioMedicine, 2022 - thelancet.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has caused a
global pandemic since late 2019 that resulted in more than 360 million population infection …

[HTML][HTML] AdMSC-derived exosomes alleviate acute lung injury via transferring mitochondrial component to improve homeostasis of alveolar macrophages

L Xia, C Zhang, N Lv, Z Liang, T Ma, H Cheng, Y Xia… - Theranostics, 2022 - ncbi.nlm.nih.gov
Rationale: Aberrant activation of macrophages with mitochondria dismiss was proved to be
associated with pathogenesis of ALI (acute lung injury). Exosomes from adipose-derived …

Mesenchymal stromal cells modulate macrophages in clinically relevant lung injury models by extracellular vesicle mitochondrial transfer

TJ Morrison, MV Jackson, EK Cunningham… - American journal of …, 2017 - atsjournals.org
Rationale: Acute respiratory distress syndrome (ARDS) remains a major cause of respiratory
failure in critically ill patients. Mesenchymal stromal cells (MSCs) are a promising candidate …

Mitochondrial transfer via tunneling nanotubes is an important mechanism by which mesenchymal stem cells enhance macrophage phagocytosis in the in vitro and in …

MV Jackson, TJ Morrison, DF Doherty, DF McAuley… - Stem …, 2016 - academic.oup.com
Mesenchymal stromal cells (MSC) have been reported to improve bacterial clearance in
preclinical models of Acute Respiratory Distress Syndrome (ARDS) and sepsis. The …

Biotrauma and ventilator-induced lung injury: clinical implications

GF Curley, JG Laffey, H Zhang, AS Slutsky - Chest, 2016 - Elsevier
The pathophysiological mechanisms by which mechanical ventilation can contribute to lung
injury, termed “ventilator-induced lung injury”(VILI), is increasingly well understood.“ …

Mesenchymal stem cell-derived extracellular vesicles for the treatment of acute respiratory distress syndrome

A Abraham, A Krasnodembskaya - Stem Cells Translational …, 2020 - academic.oup.com
Acute respiratory distress syndrome (ARDS) is a serious and potentially fatal acute
inflammatory lung condition which currently has no specific treatments targeting its …

Fifty Years of Research in ARDS.Cell-based Therapy for Acute Respiratory Distress Syndrome. Biology and Potential Therapeutic Value

JG Laffey, MA Matthay - American journal of respiratory and critical …, 2017 - atsjournals.org
On the basis of several preclinical studies, cell-based therapy has emerged as a potential
new therapeutic for acute respiratory distress syndrome (ARDS). Of the various cell-based …

Mesenchymal stem cells: mechanisms of potential therapeutic benefit in ARDS and sepsis

J Walter, LB Ware, MA Matthay - The Lancet Respiratory Medicine, 2014 - thelancet.com
Multipotent mesenchymal stem (stromal) cells (MSCs) have shown promising therapeutic
effects in preclinical models of both acute respiratory distress syndrome (ARDS) and sepsis …

Natural history of mesenchymal stem cells, from vessel walls to culture vessels

IR Murray, CC West, WR Hardy, AW James… - Cellular and Molecular …, 2014 - Springer
Mesenchymal stem/stromal cells (MSCs) can regenerate tissues by direct differentiation or
indirectly by stimulating angiogenesis, limiting inflammation, and recruiting tissue-specific …