The past 15 years have seen an explosion in our understanding of how cells replicate
damaged DNA and how this can lead to mutagenesis. The Y-family DNA polymerases lie at …

Ultraviolet (UV) light induces specific mutations in the cellular and skin genome such as UV-
signature and triplet mutations, the mechanism of which has been thought to involve …

Life as we know it, simply would not exist without DNA replication. All living organisms utilize
a complex machinery to duplicate their genomes and the central role in this machinery …

Microhomology-mediated end-joining (MMEJ) is an error-prone alternative double-strand
break–repair pathway that uses sequence microhomology to recombine broken DNA …

SUMMARY DNA repair and DNA damage tolerance machineries are crucial to overcome
the vast array of DNA damage that a cell encounters during its lifetime. In this review, we …

The structural features that enable replicative DNA polymerases to synthesize DNA rapidly
and accurately also limit their ability to copy damaged DNA. Direct replication of DNA …

This review focuses on eukaryotic DNA polymerase ζ (Pol ζ), the enzyme responsible for the
bulk of mutagenesis in eukaryotic cells in response to DNA damage. Pol ζ is also …

DNA interstrand crosslinks (ICLs) are induced by a number of bifunctional antitumor drugs
such as cisplatin, mitomycin C, or the nitrogen mustards as well as endogenous agents …

DNA polymerase ζ (Polζ) is an error-prone DNA polymerase involved in translesion DNA
synthesis. Polζ consists of two subunits: the catalytic REV3, which belongs to B family DNA …

DNA-damage tolerance (DDT) is employed by eukaryotic cells to bypass replication-
blocking lesions induced by DNA-damaging agents. In budding yeast Saccharomyces …