Tumour fatty acid metabolism in the context of therapy resistance and obesity

AJ Hoy, SR Nagarajan, LM Butler - Nature Reviews Cancer, 2021 - nature.com
Fatty acid metabolism is known to support tumorigenesis and disease progression as well
as treatment resistance through enhanced lipid synthesis, storage and catabolism. More …

Lipids as mediators of cancer progression and metastasis

FCE Vogel, AB Chaves-Filho, A Schulze - Nature Cancer, 2024 - nature.com
Metastasis formation is a complex process, involving multiple crucial steps, which are
controlled by different regulatory mechanisms. In this context, the contribution of cancer …

[HTML][HTML] Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy

F Yang, Y Xiao, JH Ding, X Jin, D Ma, DQ Li, JX Shi… - Cell metabolism, 2023 - cell.com
Treatment of triple-negative breast cancer (TNBC) remains challenging. Deciphering the
orchestration of metabolic pathways in regulating ferroptosis will provide new insights into …

Metabolic fitness and plasticity in cancer progression

S McGuirk, Y Audet-Delage, J St-Pierre - Trends in cancer, 2020 - cell.com
Cancer cells have enhanced metabolic needs due to their rapid proliferation. Moreover,
throughout their progression from tumor precursors to metastases, cancer cells face …

Lipid metabolism and endocrine resistance in prostate cancer, and new opportunities for therapy

GE Stoykova, IR Schlaepfer - International journal of molecular sciences, 2019 - mdpi.com
Prostate cancer (PCa) is the most common cancer in men, and more than 10% of men will
be diagnosed with PCa during their lifetime. Patients that are not cured with surgery or …

Therapy-induced lipid uptake and remodeling underpin ferroptosis hypersensitivity in prostate cancer

KD Tousignant, A Rockstroh, BLJ Poad, A Talebi… - Cancer & …, 2020 - Springer
Background Metabolic reprograming, non-mutational epigenetic changes, increased cell
plasticity, and multidrug tolerance are early hallmarks of therapy resistance in cancer. In this …

Androgen receptor signaling and metabolic and cellular plasticity during progression to castration resistant prostate cancer

T Uo, CC Sprenger, SR Plymate - Frontiers in oncology, 2020 - frontiersin.org
Metabolic reprogramming is associated with re/activation and antagonism of androgen
receptor (AR) signaling that drives prostate cancer (PCa) progression to castration …

Label-free imaging of lipid droplets in prostate cells using stimulated Raman scattering microscopy and multivariate analysis

EW Hislop, WJ Tipping, K Faulds… - Analytical …, 2022 - ACS Publications
Hyperspectral stimulated Raman scattering (SRS) microscopy is a powerful imaging
modality for the analysis of biological systems. Here, we report the application of k-means …

Prostate cancer progression: as a matter of fats

N Scaglia, YR Frontini-López, G Zadra - Frontiers in Oncology, 2021 - frontiersin.org
Advanced prostate cancer (PCa) represents the fifth cause of cancer death worldwide.
Although survival has improved with second-generation androgen signaling and Parp …

Role of lipids and lipid metabolism in prostate cancer progression and the tumor's immune environment

A Siltari, H Syvälä, YR Lou, Y Gao, TJ Murtola - Cancers, 2022 - mdpi.com
Simple Summary Cholesterol, lipids, and lipid metabolism are important in prostate cancer.
Lipid metabolism interacts with androgens which are of clear importance in prostate cancer …