Lactate in the regulation of tumor microenvironment and therapeutic approaches

KG de la Cruz-López, LJ Castro-Muñoz… - Frontiers in …, 2019 - frontiersin.org
Tumor cells must generate sufficient ATP and biosynthetic precursors in order to maintain
cell proliferation requirements. Otto Warburg showed that tumor cells uptake high amounts …

Peptides as multifunctional players in cancer therapy

SMP Vadevoo, S Gurung, HS Lee… - … & Molecular Medicine, 2023 - nature.com
Peptides exhibit lower affinity and a shorter half-life in the body than antibodies. Conversely,
peptides demonstrate higher efficiency in tissue penetration and cell internalization than …

Antimicrobial resistance and recent alternatives to antibiotics for the control of bacterial pathogens with an emphasis on foodborne pathogens

YA Helmy, K Taha-Abdelaziz, HAEH Hawwas, S Ghosh… - Antibiotics, 2023 - mdpi.com
Antimicrobial resistance (AMR) is one of the most important global public health problems.
The imprudent use of antibiotics in humans and animals has resulted in the emergence of …

Bioactive peptides: From basic research to clinical trials and commercialization

P Duffuler, KS Bhullar… - Journal of agricultural …, 2022 - ACS Publications
Chronic diseases, including metabolic diseases, have become a worldwide public health
issue. Research regarding the use of bioactive peptides or protein hydrolysates derived from …

Self-assembling peptides: From design to biomedical applications

S La Manna, C Di Natale, V Onesto… - International journal of …, 2021 - mdpi.com
Self-assembling peptides could be considered a novel class of agents able to harvest an
array of micro/nanostructures that are highly attractive in the biomedical field. By modifying …

Targeting endothelial vascular cell adhesion molecule-1 in atherosclerosis: drug discovery and development of vascular cell adhesion molecule-1–directed novel …

JR Pickett, Y Wu, LF Zacchi, HT Ta - Cardiovascular Research, 2023 - academic.oup.com
Vascular cell adhesion molecule-1 (VCAM-1) has been well established as a critical
contributor to atherosclerosis and consequently as an attractive therapeutic target for anti …

The application of biomaterials in spinal cord injury

C Feng, L Deng, YY Yong, JM Wu, DL Qin, L Yu… - International journal of …, 2023 - mdpi.com
The spinal cord and the brain form the central nervous system (CNS), which is the most
important part of the body. However, spinal cord injury (SCI) caused by external forces is …

IF-AIP: a machine learning method for the identification of anti-inflammatory peptides using multi-feature fusion strategy

S Gaffar, MT Hassan, H Tayara, KT Chong - Computers in biology and …, 2024 - Elsevier
Background: The most commonly used therapy currently for inflammatory and autoimmune
diseases is nonspecific anti-inflammatory drugs, which have various hazardous side effects …

Bioactive peptides of whey: Obtaining, activity, mechanism of action, and further applications

LB Olvera-Rosales, AE Cruz-Guerrero… - Critical Reviews in …, 2023 - Taylor & Francis
Bioactive peptides derived from diverse food proteins have been part of diverse
investigations. Whey is a rich source of proteins and components related to biological …

IL-1 inhibitors in the treatment of monogenic periodic fever syndromes: from the past to the future perspectives

H Malcova, Z Strizova, T Milota, I Striz… - Frontiers in …, 2021 - frontiersin.org
Autoinflammatory diseases (AIDs) represent a rare and heterogeneous group of disorders
characterized by recurrent episodes of inflammation and a broad range of clinical …