Colorectal cancer is a complex disease resulting from somatic genetic and epigenetic
alterations, including locus-specific CpG island methylation and global DNA or LINE-1 …

The term 'field effect'(also known as field defect, field cancerization, or field carcinogenesis)
has been used to describe a field of cellular and molecular alteration, which predisposes to …

A fundamental goal of epidemiologic research is to investigate the relationship between
exposures and disease risk. Cases of the disease are often considered a single outcome …

Renal tumor heterogeneity studies have utilized the von Hippel-Lindau VHL gene to classify
disease into molecularly defined subtypes to examine associations with etiologic risk factors …

Constitutional epimutations of tumor suppressor genes manifest as promoter methylation
and transcriptional silencing of a single allele in normal somatic tissues, thereby …

Sažetak Epigenetic mechanisms, such as DNA methylation, DNA hydroxymethylation, post-
translational modifications (PTMs) of histone proteins affecting nucleosome remodelling …

Constitutional epimutation, which is an aberration in gene expression due to an altered
epigenotype that is widely distributed in normal tissues (albeit frequently mosaic), provides …

Introduction: The complex genetic diversity among human populations results from an
assortment of factors acting at various sequential levels, including mutations, population …

Genetic and epigenetic modifications of genes involved in the key regulatory pathways play
a significant role in the pathophysiology and progression of multifactorial diseases. The …

Background Promoter methylation of O6-methylguanine-DNA methyltransferase (MGMT) is
an important predictive biomarker in glioblastoma. The T variant of the MGMT promoter …