Immune-checkpoint inhibitors and chimeric antigen receptor (CAR) T cells are
revolutionizing oncology and haematology practice. With these and other immunotherapies …

Multiple modes of cell death have been identified, each with a unique function and each
induced in a setting-dependent manner. As billions of cells die during mammalian …

Complete and accurate DNA replication requires the progression of replication forks through
DNA damage, actively transcribed regions, structured DNA and compact chromatin. Recent …

BACKGROUND The life of any organism depends on the ability of cells to accurately
recognize and eliminate harmful microbes. To detect the immense repertoire of pathogenic …

Although mutations leading to a compromised nuclear envelope cause diseases such as
muscular dystrophies or accelerated aging, the consequences of mechanically induced …

Radiotherapy is under investigation for its ability to enhance responses to immunotherapy.
However, the mechanisms by which radiation induces anti-tumour T cells remain unclear …

The recognition of microbial nucleic acids is a major mechanism by which the immune
system detects pathogens. Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a cytosolic DNA …

Detection of microbial DNA is an evolutionarily conserved mechanism that alerts the host
immune system to mount a defense response to microbial infections. However, this detection …

Micronuclei are small membrane-bounded compartments with a DNA content encapsulated
by a nuclear envelope and spatially separated from the primary nucleus. Micronuclei have …

Recognition of foreign or misplaced nucleic acids is one of the principal modes by which the
immune system detects pathogenic entities. When cytosolic DNA is sensed, a signal is …