Randomized trials may be designed and interpreted as single experiments or they may be
seen in the context of other similar or relevant evidence. The amount and complexity of …

Context Theory and simulation suggest that randomized controlled trials (RCTs) stopped
early for benefit (truncated RCTs) systematically overestimate treatment effects for the …

Background Despite the introduction of new monoclonal antibodies and oral therapies for
the treatment of ulcerative colitis, clinical remission rates remain low, underscoring the need …

Background and Methods National surveillance data show recent, marked reductions in
morbidity and mortality associated with the acquired immunodeficiency syndrome (AIDS). To …

Modelling Survival Data in Medical Research, Fourth Edition, describes the analysis of
survival data, illustrated using a wide range of examples from biomedical research. Written …

Consider a study whose design calls for the study subjects to be followed from enrollment
(time t= 0) to time t= T, at which point a primary endpoint of interest Y is to be measured. The …

Background The efficacy and safety of adding a protease inhibitor to two nucleoside
analogues to treat human immunodeficiency virus type 1 (HIV-1) infection are not clear. We …

Background The new protease inhibitors are potent inhibitors of the human
immunodeficiency virus (HIV), and in combination with other antiretroviral drugs they may be …

Background The introduction of combination antiretroviral therapy and protease inhibitors
has led to reports of falling mortality rates among people infected with HIV-1. We examined …

Antiretroviral toxicity is an increasingly important issue in the management of HIV-infected
patients. With the sustained major declines in opportunistic complications, HIV infection is a …