Genomes of animals as different as sponges and humans show conservation of global
architecture. Here we show that multiple genomic features including transposon diversity …

The nematode Caenorhabditis elegans is a popular model system in genetics, not least
because a majority of human disease genes are conserved in C. elegans. To generate a …

Gene content in genomes changes through several different processes, with gene
duplication being an important contributor to such changes. Gene duplication occurs over a …

Computational genomics is now generating very large volumes of data that have the
potential to be used to address important questions in both basic biology and biomedicine …

Gene duplication is an important process in the functional divergence of genes and
genomes. Several processes have been described that lead to duplicate gene retention …

Background Dosage balance has been described as an important process for the retention
of duplicate genes after whole genome duplication events. However, dosage balance is only …

A high level of robustness against gene deletion is observed in many organisms. However, it
is still not clear which biochemical features underline this robustness and how these are …

Abstract Heterotrimeric Heme Activator Protein (HAP) family genes are involved in the
regulation of flowering in plants. It is not clear how many HAP genes regulate heading date …

Many genes important in immunity are found as multigene families. The butyrophilin genes
are members of the B7 family, playing diverse roles in co-regulation and perhaps in antigen …

Human dihydrofolate reductase (DHFR) was previously thought to be the only enzyme
capable of the reduction of dihydrofolate to tetrahydrofolate; an essential reaction necessary …