Clear cell renal cell carcinoma ontogeny and mechanisms of lethality
The molecular features that define clear cell renal cell carcinoma (ccRCC) initiation and
progression are being increasingly defined. The TRACERx Renal studies and others that …
progression are being increasingly defined. The TRACERx Renal studies and others that …
VHL, the story of a tumour suppressor gene
L Gossage, T Eisen, ER Maher - Nature Reviews Cancer, 2015 - nature.com
Abstract Since the Von Hippel–Lindau (VHL) disease tumour suppressor gene VHL was
identified in 1993 as the genetic basis for a rare disorder, it has proved to be of wide medical …
identified in 1993 as the genetic basis for a rare disorder, it has proved to be of wide medical …
The PI3K/AKT pathway and renal cell carcinoma
H Guo, P German, S Bai, S Barnes, W Guo, X Qi… - Journal of genetics and …, 2015 - Elsevier
The phosphatidylinositol 3 kinase (PI3K)/AKT pathway is genetically targeted in more
pathway components and in more tumor types than any other growth factor signaling …
pathway components and in more tumor types than any other growth factor signaling …
New strategies in renal cell carcinoma: targeting the genetic and metabolic basis of disease
R Srinivasan, CJ Ricketts, C Sourbier… - Clinical cancer research, 2015 - AACR
The development of new forms of treatment of advanced renal cell carcinoma over the past
two decades has been primarily focused on targeting the VHL/HIF pathway. The recent …
two decades has been primarily focused on targeting the VHL/HIF pathway. The recent …
Targeting tumor suppressor genes for cancer therapy
Cancer drugs are broadly classified into two categories: cytotoxic chemotherapies and
targeted therapies that specifically modulate the activity of one or more proteins involved in …
targeted therapies that specifically modulate the activity of one or more proteins involved in …
Deubiquitylase OTUD6B governs pVHL stability in an enzyme‐independent manner and suppresses hepatocellular carcinoma metastasis
X Liu, X Zhang, Z Peng, C Li, Z Wang… - Advanced …, 2020 - Wiley Online Library
Hypoxia inducible factors (HIFs) are the key transcription factors that allow cancer cells to
survive hypoxia. HIF's stability is mainly controlled by von Hippel–Lindau (pVHL)‐mediated …
survive hypoxia. HIF's stability is mainly controlled by von Hippel–Lindau (pVHL)‐mediated …
Ubiquitination and regulation of AURKA identifies a hypoxia-independent E3 ligase activity of VHL
The hypoxia-regulated tumor-suppressor von Hippel-Lindau (VHL) is an E3 ligase that
recognizes its substrates as part of an oxygen-dependent prolyl hydroxylase (PHD) reaction …
recognizes its substrates as part of an oxygen-dependent prolyl hydroxylase (PHD) reaction …
[HTML][HTML] USP9X destabilizes pVHL and promotes cell proliferation
C Zhang, Z Peng, M Zhu, P Wang, X Du, X Li, Y Liu… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Numerous mutations of the Von Hippel-Lindau (VHL) gene have been reported to cause
dysfunction of VHL protein (pVHL) and lead to processes related to tumor progression …
dysfunction of VHL protein (pVHL) and lead to processes related to tumor progression …
Extraneuraxial hemangioblastoma: a clinicopathologic study of 10 cases with molecular analysis of the VHL gene
LA Muscarella, M Bisceglia, CA Galliani, N Zidar… - … -Research and Practice, 2018 - Elsevier
Less than 250 extraneuraxial hemangioblastomas occurring in paraneuraxial or peripheral
sites have been reported to date, sporadically or in the setting of von Hippel-Lindau disease …
sites have been reported to date, sporadically or in the setting of von Hippel-Lindau disease …
The prefoldin complex stabilizes the von Hippel-Lindau protein against aggregation and degradation
Loss of von Hippel-Lindau protein pVHL function promotes VHL diseases, including
sporadic and inherited clear cell Renal Cell Carcinoma (ccRCC). Mechanisms controlling …
sporadic and inherited clear cell Renal Cell Carcinoma (ccRCC). Mechanisms controlling …