Local drug delivery systems as therapeutic strategies against periodontitis: A systematic review

Y Wei, Y Deng, S Ma, M Ran, Y Jia, J Meng… - Journal of Controlled …, 2021 - Elsevier
Periodontitis is a chronic inflammation of the soft tissue surrounding and supporting the
teeth, which causes periodontal structural damage, alveolar bone resorption, and even tooth …

Periodontal and peri-implant diseases and systemically administered statins: A systematic review

F Di Spirito, L Schiavo, V Pilone, A Lanza, L Sbordone… - Dentistry Journal, 2021 - mdpi.com
Hyperlipidemia is a well-recognized risk factor for cardiovascular disease, which, in turn,
acts as a contributory factor in periodontitis development. Periodontitis has been associated …

Drugs, medications and periodontal disease

PA Heasman, FJ Hughes - British dental journal, 2014 - nature.com
This paper reviews the effects that drugs may have on the gingival and periodontal tissues.
Drug-induced gingival overgrowth has been recognised for over 70 years but is becoming a …

Pleiotropic effects of statins on the treatment of chronic periodontitis–a systematic review

IMG Estanislau, IRC Terceiro… - British journal of …, 2015 - Wiley Online Library
Aim Statins are inhibitors of 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase and are an
important group of hypolipidaemic drugs, widely used in the treatment of …

Statins and IL-1β, IL-10, and MPO levels in gingival crevicular fluid: preliminary results

V Cicek Ari, YD Ilarslan, B Erman, B Sarkarati, I Tezcan… - Inflammation, 2016 - Springer
Statins possess a wide variety of pleiotropic properties that are independent of their lipid-
lowering abilities such as attenuating inflammation, oxidative stress, coagulation, platelet …

Development and in vitro evaluation of chitosan based system for local delivery of atorvastatin for treatment of periodontitis

AI Özdoğan, G Akca, S Şenel - European Journal of Pharmaceutical …, 2018 - Elsevier
In recent years, statin group drugs have been widely investigated in treatment of periodontal
diseases due to their anti-inflammatory effect. The efficacy of statins can be enhanced by …

Association of simvastatin and hyperlipidemia with periodontal status and bone metabolism markers

A Magán‐Fernández, L Papay‐Ramírez… - Journal of …, 2014 - Wiley Online Library
Background: The objective of this study is to determine whether simvastatin consumption
and hyperlipidemia are associated with a worse periodontal condition and specific bone …

Rosuvastatin Inhibits Interleukin (IL)‐8 and IL‐6 Production in Human Coronary Artery Endothelial Cells Stimulated With Aggregatibacter actinomycetemcomitans …

DF Gualtero, SM Viafara‐Garcia… - Journal of …, 2017 - Wiley Online Library
Background: Rosuvastatin exhibits anti‐inflammatory effects and reduces periodontal
diseases and atherosclerosis; however, its role in regulating periodontopathogen‐induced …

A clinico-microbiological and biochemical study evaluating the adjunctive use of antimicrobial photodynamic therapy and local drug delivery of 1.2% simvastatin gel …

S Rahman, GV Gayathri, DS Mehta - Photodiagnosis and Photodynamic …, 2020 - Elsevier
Background To evaluate and compare the efficacy of antimicrobial Photodynamic therapy
(aPDT), Local Drug Delivery (LDD) of 1.2% Simvastatin gel as an adjunct to scaling and root …

Incidence of cord around the neck and its effects on labour and neonatal outcome

K Joshi, R Saxena, M Bhat, Y Lomrod… - Advances in Human …, 2017 - journals.lww.com
Background: The umbilical cord is a narrow tube-like structure that connects the developing
baby to the placenta. Most of the nuchal cords diagnosed in early pregnancy get …