The UDP-glucuronosyltransferases: their role in drug metabolism and detoxification
Human UDP-glucuronosyltransferase (UGT) exists as a superfamily of 22 proteins, which
are divided into 5 families and 6 subfamilies on the basis of sequence identity. Members of …
are divided into 5 families and 6 subfamilies on the basis of sequence identity. Members of …
4-methylumbelliferone treatment and hyaluronan inhibition as a therapeutic strategy in inflammation, autoimmunity, and cancer
Hyaluronan (HA) is a prominent component of the extracellular matrix at many sites of
chronic inflammation, including type 1 diabetes (T1D), multiple sclerosis, and numerous …
chronic inflammation, including type 1 diabetes (T1D), multiple sclerosis, and numerous …
UDP-glucuronosyltransferases and clinical drug-drug interactions
TKL Kiang, MHH Ensom, TKH Chang - Pharmacology & therapeutics, 2005 - Elsevier
UDP-glucuronosyltransferase (UGT) enzymes catalyze the conjugation of various
endogenous substances (eg, bilirubin) and exogenous compounds (eg, drugs). The human …
endogenous substances (eg, bilirubin) and exogenous compounds (eg, drugs). The human …
First-pass metabolism via UDP-glucuronosyltransferase: a barrier to oral bioavailability of phenolics
Glucuronidation mediated by UDP-glucuronosyltransferases (UGTs) is a significant
metabolic pathway that facilitates efficient elimination of numerous endobiotics and …
metabolic pathway that facilitates efficient elimination of numerous endobiotics and …
The role of drug metabolizing enzymes in clearance
L Di - Expert opinion on drug metabolism & toxicology, 2014 - Taylor & Francis
Introduction: Metabolism is one of the most important clearance pathways representing the
major clearance route of 75% drugs. The four most common drug metabolizing enzymes …
major clearance route of 75% drugs. The four most common drug metabolizing enzymes …
4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3
A Kultti, S Pasonen-Seppänen, M Jauhiainen… - Experimental cell …, 2009 - Elsevier
Hyaluronan accumulation on cancer cells and their surrounding stroma predicts an
unfavourable disease outcome, suggesting that hyaluronan enhances tumor growth and …
unfavourable disease outcome, suggesting that hyaluronan enhances tumor growth and …
Renal drug metabolism in humans: the potential for drug–endobiotic interactions involving cytochrome P450 (CYP) and UDP‐glucuronosyltransferase (UGT)
KM Knights, A Rowland… - British journal of clinical …, 2013 - Wiley Online Library
Although knowledge of human renal cytochrome P450 (CYP) and UDP‐
glucuronosyltransferase (UGT) enzymes and their role in xenobiotic and endobiotic …
glucuronosyltransferase (UGT) enzymes and their role in xenobiotic and endobiotic …
[PDF][PDF] Introduction to in vitro estimation of metabolic stability and drug interactions of new chemical entities in drug discovery and development
P Baranczewski, A Stanczak, K Sundberg… - Pharmacological …, 2006 - if-pan.krakow.pl
Determination of metabolic properties of a new chemical entity (NCE) is one of the most
important steps during the drug discovery and development process. Nowadays, in vitro …
important steps during the drug discovery and development process. Nowadays, in vitro …
Metabolism and bioactivation of toxicants in the lung. The in vitro cellular approach
JV Castell, MT Donato, MJ Gómez-Lechón - Experimental and Toxicologic …, 2005 - Elsevier
Lung is a target organ for the toxicity of inhalated compounds. The respiratory tract is
frequently exposed to elevated concentrations of these compounds and become the primary …
frequently exposed to elevated concentrations of these compounds and become the primary …
Drug-drug interactions that alter the exposure of glucuronidated drugs: Scope, UDP-glucuronosyltransferase (UGT) enzyme selectivity, mechanisms (inhibition and …
Drug-drug interactions (DDIs) arising from the perturbation of drug metabolising enzyme
activities represent both a clinical problem and a potential economic loss for the …
activities represent both a clinical problem and a potential economic loss for the …