Fast motions (femtosecond to picosecond) and their potential involvement during enzyme-
catalysed reactions have ignited considerable interest in recent years. Their influence on …

Asymmetric hydrogenation of activated alkenes catalysed by ene-reductases from the old
yellow enzyme family (OYEs) leading to chiral products is of potential interest for industrial …

The search for affordable, green biocatalytic processes is a challenge for chemicals
manufacture. Redox biotransformations are potentially attractive, but they rely on unstable …

Even though quantum mechanical tunnelling has been appearing recurrently mostly in
theoretical studies that emphasize its decisive role for many chemical reactions, it still …

This paper is a response to an invitation to share my viewpoint by writing an opinion piece
(not a review) on proton tunneling, especially from the point of view of whether it has a …

Coupling of fast protein dynamics to enzyme chemistry is controversial and has ignited
considerable debate, especially over the past 15 years in relation to enzyme-catalyzed H …

Choline oxidase catalyzes the oxidation of choline to glycine betaine, a compatible solute
that accumulates in pathogenic bacteria and plants so they can withstand osmotic and …

Use of the pressure dependence of kinetic isotope effects, coupled with a study of their
temperature dependence, as a probe for promoting motions in enzymatic hydrogen …

Kinetic Isotope effects (KIEs) have long served as a probe for the mechanisms of both
enzymatic and solution reactions. Here, we discuss various models for the physical sources …

Secondary deuterium isotope effects (IEs) on acidities have been accurately measured by
an NMR titration method applicable to a mixture of isotopologues. Deuteration definitely …