Inflammation underpins and contributes to the pathogenesis of many retinal degenerative
diseases. The recruitment and activation of both resident microglia and recruited …

Purpose To review the pathogenesis of uveitis in light of recent advances in our
understanding of innate and adaptive immune responses and their regulation. Design …

Microglia have been implicated in many degenerative eye disorders, including retinitis
pigmentosa, age-related macular degeneration, glaucoma, diabetic retinopathy, uveitis, and …

This study aimed to evaluate the role of interleukin (IL)-1 inhibitors anakinra (ANA) and
canakinumab (CAN) in the treatment of Behçet's disease (BD)-related uveitis. Multicenter …

Pyroptosis is a lytic form of programmed cell death mediated by gasdermins (GSDMs) with
pore-forming activity in response to certain exogenous and endogenous stimuli. The …

Increasing evidence has suggested that T helper 17 (Th17) cells play a central role in the
pathogenesis of ocular immune disease. The association between pathogenic Th17 cells …

Immune privilege (IP), a term introduced to explain the unpredicted acceptance of allogeneic
grafts by the eye and the brain, is considered a unique property of these tissues. However …

Purpose: To identify factors associated with sustained response to interleukin (IL)-1
inhibition among demographic, clinical and therapeutic data in patients with Behçet disease …

Uveitis is a complex ocular inflammatory disease often accompanied by bacterial or viral
infections (infectious uveitis) or underlying autoimmune diseases (non-infectious uveitis) …

Objectives Both innate and adaptive immune responses are reportedly increased in
Behçet's disease (BD), a chronic, relapsing systemic vasculitis lying at the intersection …