Disease overview Chronic lymphocytic leukemia (CLL) is one of the most frequent types of
leukemia. It typically occurs in elderly patients and has a highly variable clinical course …

Stroke is the leading cause of disability and thesecond leading cause of death worldwide.
With the global population aged 65 and over growing faster than all other age groups, the …

Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic
regulation is a heritable change in gene expressions independent of nucleotide sequence …

The incidence and mortality rate of cancer has been quickly increasing in the past decades.
At present, cancer has become the leading cause of death worldwide. Most of the cancers …

For decades, research into cancer biology focused on the involvement of protein-coding
genes. Only recently was it discovered that an entire class of molecules, termed non-coding …

MicroRNAs (miRNAs) are∼ 22 nt RNAs that direct posttranscriptional repression of mRNA
targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs …

In just over two decades since the discovery of the first microRNA (miRNA), the field of
miRNA biology has expanded considerably. Insights into the roles of miRNAs in …

MicroRNAs (miRNAs) are endogenous, small non-coding RNAs that function in regulation of
gene expression. Compelling evidences have demonstrated that miRNA expression is …

The observation that BRCA1-and BRCA2-deficient cells are sensitive to inhibitors of poly
(ADP–ribose) polymerase (PARP) has spurred the development of cancer therapies that use …

Metastasis is the primary cause of death of cancer patients. Dissecting mechanisms
governing metastatic spread may uncover important tumor biology and/or yield promising …