Toxoplasma gondii infection and its implications within the central nervous system
SK Matta, N Rinkenberger, IR Dunay… - Nature Reviews …, 2021 - nature.com
Toxoplasma gondii is a parasite that infects a wide range of animals and causes zoonotic
infections in humans. Although it normally only results in mild illness in healthy individuals …
infections in humans. Although it normally only results in mild illness in healthy individuals …
Epidemiology of and diagnostic strategies for toxoplasmosis
F Robert-Gangneux, ML Dardé - Clinical microbiology reviews, 2012 - Am Soc Microbiol
The apicomplexan parasite Toxoplasma gondii was discovered a little over 100 years ago,
but knowledge of its biological life cycle and its medical importance has grown in the last 40 …
but knowledge of its biological life cycle and its medical importance has grown in the last 40 …
[HTML][HTML] A genome-wide CRISPR screen in Toxoplasma identifies essential apicomplexan genes
Apicomplexan parasites are leading causes of human and livestock diseases such as
malaria and toxoplasmosis, yet most of their genes remain uncharacterized. Here, we …
malaria and toxoplasmosis, yet most of their genes remain uncharacterized. Here, we …
Toxoplasma Effectors Targeting Host Signaling and Transcription
Early electron microscopy studies revealed the elaborate cellular features that define the
unique adaptations of apicomplexan parasites. Among these were bulbous rhoptry (ROP) …
unique adaptations of apicomplexan parasites. Among these were bulbous rhoptry (ROP) …
Modulators of the balance between M1 and M2 macrophages during pregnancy
YH Zhang, M He, Y Wang, AH Liao - Frontiers in immunology, 2017 - frontiersin.org
Macrophages are a subset of mononuclear phagocytes of the innate immune system with
high plasticity and heterogeneity. At the maternal–fetal interface, macrophages are present …
high plasticity and heterogeneity. At the maternal–fetal interface, macrophages are present …
Modulation of innate immunity by Toxoplasma gondii virulence effectors
Toxoplasma gondii is a common parasite of animals and humans and can cause serious
opportunistic infections. However, the majority of infections are asymptomatic, possibly …
opportunistic infections. However, the majority of infections are asymptomatic, possibly …
Efficient gene disruption in diverse strains of Toxoplasma gondii using CRISPR/CAS9
Toxoplasma gondii has become a model for studying the phylum Apicomplexa, in part due
to the availability of excellent genetic tools. Although reverse genetic tools are available in a …
to the availability of excellent genetic tools. Although reverse genetic tools are available in a …
Local admixture of amplified and diversified secreted pathogenesis determinants shapes mosaic Toxoplasma gondii genomes
Toxoplasma gondii is among the most prevalent parasites worldwide, infecting many wild
and domestic animals and causing zoonotic infections in humans. T. gondii differs …
and domestic animals and causing zoonotic infections in humans. T. gondii differs …
Globally diverse Toxoplasma gondii isolates comprise six major clades originating from a small number of distinct ancestral lineages
Marked phenotypic variation characterizes isolates of Toxoplasma gondii, a ubiquitous
zoonotic parasite that serves as an important experimental model for studying apicomplexan …
zoonotic parasite that serves as an important experimental model for studying apicomplexan …
[HTML][HTML] A cluster of interferon-γ-inducible p65 GTPases plays a critical role in host defense against Toxoplasma gondii
M Yamamoto, M Okuyama, JS Ma, T Kimura… - Immunity, 2012 - cell.com
Summary Interferon-γ (IFN-γ) is essential for host defense against intracellular pathogens.
Stimulation of innate immune cells by IFN-γ upregulates∼ 2,000 effector genes such as …
Stimulation of innate immune cells by IFN-γ upregulates∼ 2,000 effector genes such as …