Due to the advantages in efficacy and safety compared with traditional chemotherapy drugs,
targeted therapeutic drugs have become mainstream cancer treatments. Since the first …

Ferroptosis is a new type of oxidative regulated cell death (RCD) driven by iron-dependent
lipid peroxidation. As major sites of iron utilization and master regulators of oxidative …

The global burden of hepatocellular carcinoma (HCC) is increasing and might soon surpass
an annual incidence of 1 million cases. Genomic studies have established the landscape of …

Ferroptosis, a form of regulated cell death, is initiated by oxidative perturbations of the
intracellular microenvironment, which is under the constitutive control of glutathione …

Despite advances in the treatment of cancers through surgical procedures and new
pharmaceuticals, the treatment of hepatocellular carcinoma (HCC) remains challenging as …

SLC7A11/xCT is an antiporter that mediates the uptake of extracellular cystine in exchange
for glutamate. Cystine is reduced to cysteine, which is a rate-limiting precursor in glutathione …

Angiogenesis is a significant event in a wide range of healthy and diseased conditions. This
process frequently involves vasodilation and an increase in vascular permeability …

Background & Aims Transarterial chemoembolization with doxorubicin-eluting beads (DC
Bead®; DEB-TACE) is effective in patients with Barcelona clinic liver cancer stage B …

Exchange of extracellular cystine for intracellular glutamate by the antiporter system xc− is
implicated in numerous pathologies. Pharmacological agents that inhibit system xc− activity …

1.1. Brief Historical Overview As expected from the fluorine position on the periodic table of
elements, it possesses some extreme properties, in particular, ultimate electronegativity and …