Sox family transcription factors are well-established regulators of cell fate decisions during
development. Accumulating evidence documents that they play additional roles in adult …

Over the past decade, it has become increasingly obvious that epigenetic mechanisms are
an integral part of a multitude of brain functions that range from the development of the …

Cell fate decisions are fundamental for development, but we do not know how transcriptional
networks reorganize during the transition from a pluripotent to a differentiated cell state …

An obstacle in the treatment of human diseases such as cancer is the inability to selectively
and effectively target historically undruggable targets such as transcription factors. Here, we …

We have developed a renewable, scalable and transgene free human blood-brain barrier
model, composed of brain endothelial cells (BECs), generated from human amniotic fluid …

We undertook this study to understand how the transcription factor Sox2 contributes to the
malignant phenotype of glioblastoma multiforme (GBM), the most aggressive primary brain …

Epigenetic reprogramming plays a pivotal role during embryogenesis, including both
covalent and non-covalent modifications to chromatin. In this study, we investigated the role …

Regulatory DNA elements such as enhancers, silencers and insulators are embedded in
metazoan genomes, and they control gene expression during development. Although they …

The Sox2 gene is a key regulator of pluripotency embedded within an intron of a long
noncoding RNA (ncRNA), termed Sox2 overlapping transcript (Sox2ot), which is transcribed …

SOX2 is a transcription factor conserved throughout vertebrate evolution, whose expression
marks the central nervous system from the earliest developmental stages. In humans, SOX2 …