Research conducted over the past several decades has revolutionized our understanding of
the role of the immune system in neural and psychological development and function across …

Psychological stress during childhood and adolescence increases risk of health problems
across the lifecourse, and inflammation is implicated as an underlying mechanism. To …

Depression onset peaks during adolescence and young adulthood. Current treatments are
only moderately effective, driving the search for novel pathophysiological mechanisms …

Exposure to early life stress (ELS) may lead to long-lasting neurobiological and behavioral
impairments. Alterations in the immune system and neuroinflammatory state induced by ELS …

The brain and immune system are intricately connected, and perturbations in one system
have direct effects on the other. This review focuses on these dynamic psychoneuroimmune …

Losing a spouse is considered one of the most stressful life events a person can experience.
Particularly in the immediate weeks and months after the loss, bereavement is associated …

Decades of research in animals and humans show that inflammation is an important
regulator of social behavior. While much research in this area has concluded that …

Inflammation has been shown to predict depression, but sensitivity to inflammation varies
across individuals. Experimental studies administering potent pro-inflammatory agents have …

Depression is the most common mental disorder and has become a heavy burden in
modern society. Clinical studies have identified early life stress as one of the high-risk …

Recent evidence suggests differential patterns of social behavior following an inflammatory
challenge, such that increases in inflammation may not uniformly lead to social withdrawal …