[HTML][HTML] Potential and therapeutic roles of diosmin in human diseases

E Huwait, M Mobashir - Biomedicines, 2022 - mdpi.com
Because of their medicinal characteristics, effectiveness, and importance, plant-derived
flavonoids have been a possible subject of research for many years, particularly in the last …

Metabolism and pharmacological activities of the natural health-benefiting compound diosmin

Y Zheng, R Zhang, W Shi, L Li, H Liu, Z Chen, L Wu - Food & function, 2020 - pubs.rsc.org
Diosmin is a famous natural flavonoid for treating chronic venous insufficiency and varicose
veins. Recently, extensive study has indicated that diosmin possesses diverse …

Antioxidant and anti-inflammatory properties of flavonoids from lotus plumule

GL Chen, MX Fan, JL Wu, N Li, MQ Guo - Food chemistry, 2019 - Elsevier
The antioxidant and anti-inflammatory mechanisms of action of flavonoids in lotus plumule
were systematically analyzed using radical scavenging assays and ELISA kits. By this …

Pharmacology of diosmin, a citrus flavone glycoside: an updated review

SH Gerges, SA Wahdan, DA Elsherbiny… - European journal of …, 2022 - Springer
Flavonoids are phytochemicals that are well known for their beneficial pharmacological
properties. Diosmin is a flavone glycoside derived from hesperidin, a flavanone abundantly …

Diosmin attenuates methotrexate‐induced hepatic, renal, and cardiac injury: A biochemical and histopathological study in mice

MM Abdel-Daim, HA Khalifa… - Oxidative medicine …, 2017 - Wiley Online Library
The current study was designed to investigate the beneficial role of diosmin, a biologically
active flavonoid, against methotrexate‐(MTX‐) induced hepatic, renal, and cardiac injuries in …

Ablation of endothelial Pfkfb3 protects mice from acute lung injury in LPS-induced endotoxemia

L Wang, Y Cao, B Gorshkov, Y Zhou, Q Yang… - Pharmacological …, 2019 - Elsevier
Acute lung injury (ALI) is one of the leading causes of death in sepsis. Endothelial
inflammation and dysfunction play a prominent role in development of ALI. Glycolysis is the …

Flavonoids as potential phytotherapeutics to combat cytokine storm in SARS‐CoV‐2

A Gour, D Manhas, S Bag, B Gorain… - Phytotherapy …, 2021 - Wiley Online Library
Emergence of severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection,
COVID‐19, has become the global panic since December 2019, which urges the global …

[HTML][HTML] Resveratrol mitigates lipopolysaccharide-mediated acute inflammation in rats by inhibiting the TLR4/NF-κBp65/MAPKs signaling cascade

G Wang, Z Hu, Q Fu, X Song, Q Cui, R Jia, Y Zou… - Scientific reports, 2017 - nature.com
Resveratrol (RSV) is a natural compound exhibiting anti-inflammatory effect, but the anti-
inflammatory mechanism has not been fully understood. This study is aimed to evaluate the …

Design, synthesis and evaluation of ursodeoxycholic acid-cinnamic acid hybrids as potential anti-inflammatory agents by inhibiting Akt/NF-κB and MAPK signaling …

X Li, Y Hu, B He, L Li, Y Tian, Y Xiao, H Shang… - European Journal of …, 2023 - Elsevier
A series of ursodeoxycholic acid (UDCA)-cinnamic acid hybrids were designed and
synthesized. The anti-inflammatory activity of these derivatives was screened through …

[HTML][HTML] Diosmin mitigates dexamethasone-induced osteoporosis in vivo: Role of Runx2, RANKL/OPG, and oxidative stress

ESA Arafa, NO Elgendy, MA Elhemely… - Biomedicine & …, 2023 - Elsevier
Secondary osteoporosis is commonly caused by long-term intake of glucocorticoids (GCs),
such as dexamethasone (DEX). Diosmin, a natural substance with potent antioxidant and …