Development of innovative biomaterials and devices for the treatment of cardiovascular diseases

Y Wang, G Li, L Yang, R Luo, G Guo - Advanced Materials, 2022 - Wiley Online Library
Cardiovascular diseases have become the leading cause of death worldwide. The
increasing burden of cardiovascular diseases has become a major public health problem …

A materials science vision of extracellular matrix mineralization

N Reznikov, JAM Steele, P Fratzl… - Nature Reviews …, 2016 - nature.com
From an engineering perspective, skeletal tissues are remarkable structures because they
are lightweight, stiff and tough, yet produced at ambient conditions. The biomechanical …

A review of decellurization methods caused by an urgent need for quality control of cell‐free extracellular matrix'scaffolds and their role in regenerative medicine

M Kawecki, W Łabuś, A Klama‐Baryla… - … Research Part B …, 2018 - Wiley Online Library
The natural extracellular matrix (ECM), thanks to its specific properties (eg, collagenous
lattice, a reservoir of growth factors, ECM‐cell anchoring areas, an optimal pH and CO2) …

Heart valves cross-linked with erythrocyte membrane drug-loaded nanoparticles as a biomimetic strategy for anti-coagulation, anti-inflammation, anti-calcification, and …

C Hu, R Luo, Y Wang - ACS Applied Materials & Interfaces, 2020 - ACS Publications
In recent years, valvular heart disease has become a serious disease threatening human life
and is a major cause of death worldwide. However, the glutaraldehyde (GLU)-treated …

Radical polymerization-crosslinking method for improving extracellular matrix stability in bioprosthetic heart valves with reduced potential for calcification and …

G Guo, L Jin, W Jin, L Chen, Y Lei, Y Wang - Acta biomaterialia, 2018 - Elsevier
In recent years, the number of heart valve replacements has multiplied with valve diseases
because of aging populations and the surge in rheumatic heart disease in young people …

Age-related enhanced degeneration of bioprosthetic valves due to leaflet calcification, tissue crosslinking, and structural changes

Y Xue, AP Kossar, A Abramov, A Frasca… - Cardiovascular …, 2023 - academic.oup.com
Abstract Aims Bioprosthetic heart valves (BHVs), made from glutaraldehyde-fixed heterograft
materials, are subject to more rapid structural valve degeneration (SVD) in paediatric and …

Polyzwitterion-crosslinked hybrid tissue with antithrombogenicity, endothelialization, anticalcification properties

F Yang, L Xu, D Kuang, Y Ge, G Guo, Y Wang - Chemical Engineering …, 2021 - Elsevier
Although transcatheter aortic valve implantation (TAVI) has been proven with excellent
effectiveness and safety, the subclinical leaflet thrombosis (SLT) and structural valve …

Chemical bonding of biological valve leaflets with an aminated zwitterionic copolymer for long-term anticoagulation and improved anti-calcification

K Liu, M Li, F Zhang, Y Wang, C Chen, Y Wei… - Chemical Engineering …, 2021 - Elsevier
Glutaraldehyde cross-linked pericardium (GLUT), mostly used in Bioprosthetic heart valves
(BHVs) clinically, still has problems of valve thrombus, cytotoxicity, and calcification …

Fixation of bovine pericardium-based tissue biomaterial with irreversible chemistry improves biochemical and biomechanical properties

H Tam, W Zhang, D Infante, N Parchment… - Journal of …, 2017 - Springer
Bioprosthetic heart valves (BHVs), derived from glutaraldehyde crosslinked (GLUT) porcine
aortic valve leaflets or bovine pericardium (BP), are used to replace defective heart valves …

Comparison of natural crosslinking agents for the stabilization of xenogenic articular cartilage

A Pinheiro, A Cooley, J Liao… - Journal of orthopaedic …, 2016 - Wiley Online Library
Osteochondral xenografts are potentially inexpensive, widely available alternatives to fresh
allografts. However, antigen removal from xenogenic cartilage may damage the extracellular …