Antibacterial resistance is one of the greatest threats to human health. The development of
new therapeutics against bacterial pathogens has slowed drastically since the approvals of …

Tumor suppressor p53 can transcriptionally activate downstream genes in response to
stress, and then regulate the cell cycle, DNA repair, metabolism, angiogenesis, apoptosis …

Peptide-based covalent inhibitors targeted to nucleophilic protein residues have recently
emerged as new modalities to target protein–protein interactions (PPIs) as they may provide …

Cancer treatments with targeted therapy have gained immense interest due to their low
levels of toxicity and high selectivity. Proteolysis-Targeting Chimeras (PROTACs) have …

Structure–activity relationships (SARs) and structure–property relationships (SPRs) have
been considered the most important factors during the drug optimization process. For …

Peptides and peptide aptamers have emerged as promising molecules for a wide range of
biomedical applications due to their unique properties and versatile functionalities. The …

The RFamide family of peptides represents an important class of GPCR ligand
neuropeptides covering a wide range of biological functions. While many analogues of the …

The sliding DNA clamp is a ring-shaped protein that encircles DNA within its central
channel. It binds to multiple proteins, such as DNA polymerases and DNA repair enzymes …

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