Molecular Biomarkers and Recent Liquid Biopsy Testing Progress: A Review of the Application of Biosensors for the Diagnosis of Gliomas

Y Wu, X Wang, M Zhang, D Wu - Molecules, 2023 - mdpi.com
Gliomas are the most common primary central nervous system tumors, with a high mortality
rate. Early and accurate diagnosis of gliomas is critical for successful treatment. Biosensors …

[HTML][HTML] Implications of advances in studies of O6-methylguanine-DNA-methyltransferase for tumor prognosis and treatment

Y Chen, W Qu, J Tu, H Qi - Frontiers in Bioscience-Landmark, 2023 - imrpress.com
O6-methylguanine-DNA-methyltransferase (MGMT) is a DNA repair enzyme, which reverses
the alkylation of guanine O6 through directtransfer of the methyl group, maintains the gene …

Clinical Significance of Early Venous Filling Detected via Preoperative Angiography in Glioblastoma

K Tatebayashi, N Nakayama, D Sakamoto, T Iida… - Cancers, 2023 - mdpi.com
Simple Summary Our study examined early venous filling (EVF) on angiography, a potential
sign of aggressiveness in a type of brain cancer known as glioblastoma (GBM). The study …

Beyond invasive biopsies: using VASARI MRI features to predict grade and molecular parameters in gliomas

NH Setyawan, L Choridah, HA Nugroho, RG Malueka… - Cancer Imaging, 2024 - Springer
Background Gliomas present a significant economic burden and patient management
challenge. The 2021 WHO classification incorporates molecular parameters, which guide …

[Retracted] Effect of High‐Quality Nursing Based on Comprehensive Nursing on the Postoperative Quality of Life and Satisfaction of Patients with Malignant Glioma

X Gong, W Wu, D Xing, X Guo… - … and Alternative Medicine, 2022 - Wiley Online Library
Objective. To explore the effect of high‐quality nursing based on comprehensive nursing on
postoperative quality of life and satisfaction of patients with malignant glioma. Methods …

5-Methylcytosine immunohistochemistry for predicting cutaneous melanoma prognosis

J Meevassana, S Varophas, P Prabsattru… - Scientific Reports, 2024 - nature.com
There is a correlation between DNA methylation and the diseased stage and poor survival. 5-
methylcytosine (5-mC) is one of the epigenetic modifications of bases that researchers focus …

Comprehensive clinical assays for molecular diagnostics of gliomas: the current state and future prospects

A Penkova, O Kuziakova, V Gulaia, V Tiasto… - Frontiers in Molecular …, 2023 - frontiersin.org
Glioma is one of the most intractable types of cancer, due to delayed diagnosis at advanced
stages. The clinical symptoms of glioma are unclear and due to a variety of glioma subtypes …

Harnessing an emissive guanine surrogate to design small-molecule fluorescent chemosensors of O 6-methylguanine-DNA-methyltransferase (MGMT)

A Fillion, JF Pinto, A Granzhan - Organic & Biomolecular Chemistry, 2022 - pubs.rsc.org
The fluorescence properties of an emissive guanine surrogate, thienoguanine (thGN, 2-
aminothieno [3, 4-d] pyrimidin-4 (3H)-one), were exploited to design two real-time …

Glioma Grade and Molecular Markers: Comparing Machine-Learning Approaches Using VASARI (Visually AcceSAble Rembrandt Images) Radiological Assessment

NH Setyawan, L Choridah, HA Nugroho… - Cureus, 2024 - pmc.ncbi.nlm.nih.gov
Objectives: This study aimed to leverage Visually AcceSAble Rembrandt Images (VASARI)
radiological features, extracted from magnetic resonance imaging (MRI) scans, and machine …

The O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation status and clinical outcomes of Ewing sarcoma patients treated with irinotecan and …

S Salah, W Naser, O Jaber, Y Saleh… - reports of practical …, 2022 - journals.viamedica.pl
Background: There remains an unmet need to identify molecular biomarkers in Ewing
sarcoma (ES). We sought to assess the influence of the O 6-methylguanine-DNA …