Most age-related neurodegenerative diseases remain incurable owing to an incomplete
understanding of the disease mechanisms. Several environmental and genetic factors …

Skeletal muscle stem cells (MuSCs, also called satellite cells) are the source of the robust
regenerative capability of this tissue. The hallmark property of MuSCs at homeostasis is …

The burden of senescent hepatocytes correlates with the severity of metabolic dysfunction–
associated steatotic liver disease (MASLD), but the mechanisms driving senescence and …

Successful muscle regeneration relies on the interplay of multiple cell populations. However,
the signals required for this coordinated intercellular crosstalk remain largely unknown …

Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …

Adult skeletal muscle regeneration is mainly driven by muscle stem cells (MuSCs), which
are highly heterogeneous. Although recent studies have started to characterize the …

Primary cilia are specialized organelles that sense changes in extracellular milieu, and their
malfunction is responsible for several disorders (ciliopathies). Increasing evidence shows …

Notch and Hedgehog signaling are involved in cancer biology and pathology, including the
maintenance of tumor cell proliferation, cancer stem-like cells, and the tumor …

Adult tissue-specific stem cells play a dominant role in tissue homeostasis and regeneration.
Various in vivo markers of adult tissue-specific stem cells have been increasingly reported …

Age‐related skeletal muscle atrophy or sarcopenia is a significant societal problem that is
becoming amplified as the world's population continues to increase. The regeneration of …