Recent advances in triterpenoid pathway elucidation and engineering

S Dinday, S Ghosh - Biotechnology Advances, 2023 - Elsevier
Triterpenoids are among the most assorted class of specialized metabolites found in all the
taxa of living organisms. Triterpenoids are the leading active ingredients sourced from plant …

[HTML][HTML] Enzymes revolutionize the bioproduction of value-added compounds: From enzyme discovery to special applications

B Wiltschi, T Cernava, A Dennig, MG Casas… - Biotechnology …, 2020 - Elsevier
Competitive sustainable production in industry demands new and better biocatalysts,
optimized bioprocesses and cost-effective product recovery. Our review sheds light on the …

The yeast peroxisome: a dynamic storage depot and subcellular factory for squalene overproduction

GS Liu, T Li, W Zhou, M Jiang, XY Tao, M Liu… - Metabolic …, 2020 - Elsevier
Engineering microbes to produce terpenes from renewable feedstock is a promising
alternative to traditional production approaches. Generally, terpenes are not readily secreted …

Microbial production of limonene and its derivatives: Achievements and perspectives

Y Ren, S Liu, G Jin, X Yang, YJ Zhou - Biotechnology Advances, 2020 - Elsevier
Limonene and its derivatives have great market potential with diverse applications in food,
pharmaceuticals, cosmetics, etc. Commercial production of limonene and its derivatives …

Engineering yeast for the production of plant terpenoids using synthetic biology approaches

JA Bureau, ME Oliva, Y Dong, C Ignea - Natural Product Reports, 2023 - pubs.rsc.org
Covering: 2011–2022 The low amounts of terpenoids produced in plants and the difficulty in
synthesizing these complex structures have stimulated the production of terpenoid …

Genetic and bioprocess engineering to improve squalene production in Yarrowia lipolytica

H Liu, F Wang, L Deng, P Xu - Bioresource technology, 2020 - Elsevier
Squalene is the precursor for triterpene-based natural products and steroids-based drugs. It
has been widely used as pharmaceutical intermediates and personal care products. The …

Metabolic engineering of Yarrowia lipolytica for terpenoids production: advances and perspectives

G Zhang, H Wang, Z Zhang, KJ Verstrepen… - Critical Reviews in …, 2022 - Taylor & Francis
Terpenoids are a large family of natural products with diversified structures and functions
that are widely used in the food, pharmaceutical, cosmetic, and agricultural fields. However …

Metabolic engineering of Yarrowia lipolytica for improving squalene production

WY Tang, DP Wang, Y Tian, X Fan, C Wang… - Bioresource …, 2021 - Elsevier
The aim of this present research is to enhance the squalene production in Yarrowia
lipolytica using pathway engineering and bioprocess engineering. Firstly, to improve the …

Metabolic engineering and synthetic biology for isoprenoid production in Escherichia coli and Saccharomyces cerevisiae

GR Navale, MS Dharne, SS Shinde - Applied Microbiology and …, 2021 - Springer
Isoprenoids, often called terpenoids, are the most abundant and highly diverse family of
natural organic compounds. In plants, they play a distinct role in the form of photosynthetic …

[HTML][HTML] Tailored biosynthesis of gibberellin plant hormones in yeast

KR Kildegaard, JA Arnesen, B Adiego-Pérez… - Metabolic …, 2021 - Elsevier
The application of small amounts of natural plant growth hormones, such as gibberellins
(GAs), can increase the productivity and quality of many vegetable and fruit crops. However …