Virtually all living cells possess an absolute re-Ž. quirement for iron Fe, and it has been
suggested that reactions catalyzed by Fe may have constituted a wx first step in the origin of …

The N uclear F actor I (NFI) family of site-specific DNA-binding proteins (also known as CTF
or C AAT box t ranscription f actor) functions both in viral DNA replication and in the …

Optimized weight matrices defining four major eukaryotic promoter elements, the TATA-box,
cap signal, CCAAT-, and GC-box, are presented; they were derived by comparative …

Genetic Algorithms (GA) as a tool for a search and optimizing methodology has now
reached a mature stage. It has found many useful applications in both the scientific and …

Transcription factor Spl is a protein present in mammalian cells that binds to GC box
promoter elements and selectively activates mRNA synthesis from genes that contain …

The nuclear envelope is a dynamic structure that completely disassembles in response to
MPFlcdcP activity in mitosis. A key feature of this process is the hyperphosphorylation of the …

Egr-7 is an early growth response gene that displays fos-like induction kinetics in fibroblasts,
epithelial cells, and lymphocytes following mitogenic stimulation. Sequence analysis of …

The enhancer-binding protein AP-1 has been purified to> 95% homogeneity from HeLa cells
by sequencespecific DNA affinity chromatography and identified as a 47 kd polypeptide …

Warfarin, a commonly prescribed anticoagulant, exhibited large inter-individual and inter-
ethnic differences in the dose required for its anticoagulation effect. Asian populations …

Glycosylation is often regarded as being restricted to proteins confined to the cell surface or
within the lumen of intracellular organelles. Here we show that the human RNA polymerase …