The mammalian genome encodes 28 distinct members of the transient receptor potential
(TRP) superfamily of cation channels, which exhibit varying degrees of selectivity for …

Vascular endothelial growth factors (VEGFs) are key regulators of permeability. The
principal evidence behind how they increase vascular permeability in vivo and in vitro and …

Plasma membrane (PM) ion channels contribute to virtually all basic cellular processes and
are also involved in the malignant phenotype of cancer cells. Here, we review the role of ion …

Cancer involves defects in the mechanisms underlying cell proliferation, death and
migration. Calcium ions are central to these phenomena, serving as major signalling agents …

It has long been known that endothelial Ca2+ signals drive angiogenesis by recruiting
multiple Ca2+-sensitive decoders in response to pro-angiogenic cues, such as vascular …

The existence of a mammalian family of TRPC ion channels, direct homologues of TRP, the
visual transduction channel of flies, was discovered during 1995–1996 as a consequence of …

Lung vascular endothelial barrier disruption and the accompanying inflammation are
primary pathogenic features of acute lung injury (ALI); however, the basis for the …

Vasculogenesis, angiogenesis and arteriogenesis represent three crucial mechanisms
involved in the formation and maintenance of the vascular network in embryonal and post …

The transient receptor potential (TRP) channel superfamily consists of 28 mammalian cation
channels and is expressed in almost every tissue, including the heart and vasculature; most …

RhoA activation and increased intracellular Ca 2+ concentration mediated by the activation
of transient receptor potential channels (TRPC) both contribute to the thrombin-induced …