Porcine reproductive and respiratory syndrome virus (PRRSV): pathogenesis and interaction with the immune system

JK Lunney, Y Fang, A Ladinig, N Chen… - Annual review of …, 2016 - annualreviews.org
This review addresses important issues of porcine reproductive and respiratory syndrome
virus (PRRSV) infection, immunity, pathogenesis, and control. Worldwide, PRRS is the most …

Arterivirus molecular biology and pathogenesis

EJ Snijder, M Kikkert, Y Fang - Journal of General …, 2013 - microbiologyresearch.org
Arteriviruses are positive-stranded RNA viruses that infect mammals. They can cause
persistent or asymptomatic infections, but also acute disease associated with a respiratory …

Key gaps in the knowledge of the porcine respiratory reproductive syndrome virus (PRRSV)

S Montaner-Tarbes, HA Del Portillo… - Frontiers in veterinary …, 2019 - frontiersin.org
The porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most
important swine diseases in the world. It is causing an enormous economic burden due to …

Pathogenesis and control of the Chinese highly pathogenic porcine reproductive and respiratory syndrome virus

J Han, L Zhou, X Ge, X Guo, H Yang - Veterinary microbiology, 2017 - Elsevier
Porcine reproductive and respiratory syndrome virus (PRRSV) has remained a major threat
to the worldwide swine industry ever since its first discovery in the early 1990s. Under the …

Molecular evolution of PRRSV in Europe: current state of play

T Stadejek, A Stankevicius, MP Murtaugh… - Veterinary …, 2013 - Elsevier
Porcine reproductive and respiratory syndrome virus (PRRSV) is a major threat to European
swine production. The existence of extensive genetic variation in endemic strains and the …

Molecular and cellular mechanisms for PRRSV pathogenesis and host response to infection

TQ An, JN Li, CM Su, D Yoo - Virus research, 2020 - Elsevier
Porcine reproductive and respiratory syndrome virus (PRRSV) has caused tremendous
amounts of economic losses to the swine industry for more than three decades, but its …

Recent insights into the development of therapeutics against coronavirus diseases by targeting N protein

C Chang, SC Lo, YS Wang, MH Hou - Drug discovery today, 2016 - Elsevier
Highlights•Coronavirus nucleocapsid proteins are appealing drug targets against
coronavirus-induced diseases.•A variety of compounds targeting the coronavirus …

Porcine reproductive and respiratory syndrome (PRRS): an immune dysregulatory pandemic

JE Butler, KM Lager, W Golde, KS Faaberg… - Immunologic …, 2014 - Springer
Porcine reproductive and respiratory disease syndrome (PRRS) is a viral pandemic that
especially affects neonates within the “critical window” of immunological development …

Evasion strategies of porcine reproductive and respiratory syndrome virus

X Chen, S Qiao, R Li, J Wang, X Li… - Frontiers in Microbiology, 2023 - frontiersin.org
During the co-evolution of viruses and their hosts, viruses have developed various strategies
for overcoming host immunological defenses so that they can proliferate efficiently. Porcine …

Regulatory T cells in arterivirus and coronavirus infections: do they protect against disease or enhance it?

TE Cecere, SM Todd, T LeRoith - Viruses, 2012 - mdpi.com
Regulatory T cells (Tregs) are a subset of T cells that are responsible for maintaining
peripheral immune tolerance and homeostasis. The hallmark of Tregs is the expression of …