An estimated 20% of all patients with cancer will develop brain metastases, with the majority
of brain metastases occurring in those with lung, breast and colorectal cancers, melanoma …

Tumour metastasis, the movement of tumour cells from a primary site to progressively
colonize distant organs, is a major contributor to the deaths of cancer patients. Therapeutic …

Brain metastasis is a major cause of cancer mortality, but its molecular mechanisms are
severely understudied. In addition, little is known regarding the role of m 6 A reader YTHDF3 …

The development of life-threatening cancer metastases at distant organs requires
disseminated tumour cells' adaptation to, and co-evolution with, the drastically different …

Bone metastases remain a serious health concern because of limited therapeutic options.
Here, we report that crosstalk between ROR1–HER3 and the Hippo–YAP pathway promotes …

Abstract Bone metastases occur in 50–70% of patients with late-stage breast cancers and
effective therapies are needed. The expression of enhancer of zeste homolog 2 (EZH2) is …

Conventional therapies for breast cancer brain metastases (BCBMs) have been largely
ineffective because of chemoresistance and impermeability of the blood-brain barrier. A …

Metastatic tumours involving the brain overshadow primary brain neoplasms in frequency
and are an important complication in the overall management of many cancers. Importantly …

When properly employed, targeted therapies are effective cancer treatments. However, the
development of such therapies requires the identification of targetable drivers of cancer …

Despite major therapeutic advances in the management of patients with breast cancer,
central nervous system (CNS) metastases remain an intractable problem, particularly in …