DNA hybridization, wherein strands of DNA form duplex or larger hybrids through
noncovalent, sequence-specific interactions, is one of the most fundamental processes in …

Fluorescent base analogs (FBAs) are powerful probes of nucleic acids' structures and
dynamics. However, previously reported FBAs exhibit relatively low brightness and therefore …

Although blood remains a gold standard diagnostic fluid for most health exams, it involves
an unpleasant and relatively invasive sampling procedure (finger pricking or venous draw) …

The dynamics of proteins, which are essential for both folding and function, are known to be
strongly dependent on solvent viscosity or friction. However, an increasing number of …

Describing the kinetics of polymer reactions, such as the formation of loops and hairpins in
nucleic acids or polypeptides, is complicated by the structural dynamics of their chains …

Recent experiments showed that the reconfiguration dynamics of unfolded proteins are often
adequately described by simple polymer models. In particular, the Rouse model with …

A wide range of new devices aimed at in vivo molecular detection and point-of-care
diagnostics rely on binding-induced changes in electron-transfer kinetics from an electrode …

Electrode-bound, redox-reporter-modified oligonucleotides play roles in the functioning of a
number of electrochemical biosensors, and thus the question of electron transfer through or …

Glucose is the most important analyte for biosensors. Recently a DNA aptamer was reported
allowing binding‐based detection. However, due to a relatively weak binding affinity, it is …

Conformational rearrangements in biomolecules (such as protein folding or enzyme-ligand
binding) are often interpreted in terms of low-dimensional models of barrier crossing such as …