Cytokine storm and COVID-19: a chronicle of pro-inflammatory cytokines

A Fara, Z Mitrev, RA Rosalia, BM Assas - Open biology, 2020 - royalsocietypublishing.org
Coronavirus disease 2019 (COVID-19) has swept the world, unlike any other pandemic in
the last 50 years. Our understanding of the disease has evolved rapidly since the outbreak; …

Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer

SA Jones, BJ Jenkins - Nature reviews immunology, 2018 - nature.com
The IL-6 family of cytokines consists of IL-6, IL-11, IL-27, IL-31, oncostatin M (OSM),
leukaemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), cardiotrophin 1 (CT-1) …

ESPEN guideline on clinical nutrition in hospitalized patients with acute or chronic kidney disease

E Fiaccadori, A Sabatino, R Barazzoni, JJ Carrero… - Clinical Nutrition, 2021 - Elsevier
Acute kidney disease (AKD)-which includes acute kidney injury (AKI)–and chronic kidney
disease (CKD) are highly prevalent among hospitalized patients, including those in …

Pathophysiology and pathology of acute kidney injury in patients with COVID-19

JH Ng, V Bijol, MA Sparks, ME Sise, H Izzedine… - Advances in Chronic …, 2020 - Elsevier
Acute kidney injury (AKI) is common among hospitalized patients with Coronavirus
Infectious Disease 2019 (COVID-19), with the occurrence of AKI ranging from 0.5% to 80 …

Effect of early vs delayed initiation of renal replacement therapy on mortality in critically ill patients with acute kidney injury: the ELAIN randomized clinical trial

A Zarbock, JA Kellum, C Schmidt, H Van Aken… - Jama, 2016 - jamanetwork.com
Importance Optimal timing of initiation of renal replacement therapy (RRT) for severe acute
kidney injury (AKI) but without life-threatening indications is still unknown. Objective To …

Cisplatin‐induced rodent model of kidney injury: characteristics and challenges

M Perše, Ž Večerić-Haler - BioMed research international, 2018 - Wiley Online Library
Cisplatin is an antitumor drug used in the treatment of a wide variety of malignancies.
However, its primary dose‐limiting side effect is kidney injury, which is a major clinical …

Distant organ dysfunction in acute kidney injury: a review

SA Lee, M Cozzi, EL Bush, H Rabb - American journal of kidney diseases, 2018 - Elsevier
Acute kidney injury (AKI) is common in critically ill patients and is associated with increased
morbidity and mortality. Dysfunction of other organs is an important cause of poor outcomes …

Update on mechanisms of ischemic acute kidney injury

P Devarajan - Journal of the American Society of Nephrology, 2006 - journals.lww.com
Acute renal failure (ARF), classically defined as an abrupt decrease in kidney function that
leads to accumulation of nitrogenous wastes such as blood urea nitrogen and creatinine, is …

Mediators of inflammation in acute kidney injury

A Akcay, Q Nguyen, CL Edelstein - Mediators of inflammation, 2009 - Wiley Online Library
Acute kidney injury (AKI) remains to be an independent risk factor for mortality and morbidity.
Inflammation is now believed to play a major role in the pathopathophysiology of AKI. It is …

[HTML][HTML] Biomarkers for the diagnosis and risk stratification of acute kidney injury: a systematic review

SG Coca, R Yalavarthy, J Concato, CR Parikh - Kidney international, 2008 - Elsevier
The diagnosis of acute kidney injury (AKI) is usually based on changes in serum creatinine,
but such measurements are a poor marker of acute deterioration in kidney function. We …