Complex coacervation is an associative, liquid–liquid phase separation that can occur in
solutions of oppositely-charged macromolecular species, such as proteins, polymers, and …

Isothermal titration calorimetry has routinely been used to understand the thermodynamic
characteristics of complexation and coacervation. Most commonly, built-in models that …

Driving forces for association between oppositely charged biological or synthetic polymers
in aqueous solution have long been identified as electrostatic in origin. This attraction is …

Liquid–liquid phase separation is responsible for formation of P granules, nucleoli, and
other membraneless subcellular organelles composed of RNA and proteins. Efforts to …

Disordered proteins play an essential role in a wide variety of biological processes, and are
often posttranslationally modified. One such protein is histone H1; its highly disordered C …

Highly disordered complexes between oppositely charged intrinsically disordered proteins
present a new paradigm of biomolecular interactions. Here, we investigate the driving forces …

Oppositely charged polyelectrolytes in solution spontaneously associate into hydrated
complexes or coacervates, PECs. The morphology, stability, and properties of PECs depend …

Coacervation is a liquid–liquid phase separation that can occur in solutions of
macromolecules through self-assembly or electrostatic interactions. Recently, coacervates …

Individual amphiphiles, polymers, and colloidal dispersions influenced by temperature, pH,
and environmental conditions or interactions between their oppositely charged pairs in …

Polyelectrolyte complexes (PECs) offer enormous material tunability and desirable
functionalities, and consequently have found broad utility in biomedical and material …