In vitro models for non-alcoholic fatty liver disease: Emerging platforms and their applications
MJ Ramos, L Bandiera, F Menolascina, JA Fallowfield - Iscience, 2022 - cell.com
Non-alcoholic fatty liver disease (NAFLD) represents a global healthcare challenge,
affecting 1 in 4 adults, and death rates are predicted to rise inexorably. The progressive form …
affecting 1 in 4 adults, and death rates are predicted to rise inexorably. The progressive form …
The influence of dietary fatty acids on liver fat content and metabolism
L Hodson, F Rosqvist, SA Parry - Proceedings of the Nutrition Society, 2020 - cambridge.org
Non-alcoholic fatty liver disease encompasses a spectrum of conditions from hepatic
steatosis through to cirrhosis; obesity is a known risk factor. The liver plays a major role in …
steatosis through to cirrhosis; obesity is a known risk factor. The liver plays a major role in …
Adipose tissue dysfunction and visceral fat are associated with hepatic insulin resistance and severity of NASH even in lean individuals
Abstract Background & Aims Non‐alcoholic fatty liver disease (NAFLD) is a heterogeneous
disorder, but the factors that determine this heterogeneity remain poorly understood …
disorder, but the factors that determine this heterogeneity remain poorly understood …
[HTML][HTML] Effects of TM6SF2 E167K on hepatic lipid and very low-density lipoprotein metabolism in humans
Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic lipid accumulation. The
transmembrane 6 superfamily member 2 (TM6SF2) E167K genetic variant associates with …
transmembrane 6 superfamily member 2 (TM6SF2) E167K genetic variant associates with …
In vivo and in vitro models of hepatocellular carcinoma: current strategies for translational modeling
GR Romualdo, K Leroy, CJS Costa, GB Prata… - Cancers, 2021 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) is a highly incident and deadly malignant
neoplasia, and only a few anti-HCC drugs are currently available. Thus, the development of …
neoplasia, and only a few anti-HCC drugs are currently available. Thus, the development of …
Metabolic role of the hepatic valine/3-hydroxyisobutyrate (3-HIB) pathway in fatty liver disease
MS Bjune, L Lawrence-Archer, J Laupsa-Borge… - …, 2023 - thelancet.com
Background The valine (branched-chain amino acid) metabolite 3-hydroxyisobutyrate (3-
HIB), produced by 3-Hydroxyisobutyryl-CoA Hydrolase (HIBCH), is associated with insulin …
HIB), produced by 3-Hydroxyisobutyryl-CoA Hydrolase (HIBCH), is associated with insulin …
Associations between types and sources of dietary carbohydrates and liver fat: a UK Biobank study
Background and aims Excess energy intake can lead to metabolic dysfunction-associated
steatotic liver disease (MASLD), but the relationship between dietary carbohydrate intake …
steatotic liver disease (MASLD), but the relationship between dietary carbohydrate intake …
[HTML][HTML] Customized liver organoids as an advanced in vitro modeling and drug discovery platform for non-alcoholic fatty liver diseases
DW Han, KH Xu, ZL Jin, YN Xu, YH Li… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Non-alcoholic fatty liver disease (NAFLD) and its progressive form non-alcoholic
steatohepatitis (NASH) have presented a major and common health concern worldwide due …
steatohepatitis (NASH) have presented a major and common health concern worldwide due …
A comparison of primary human hepatocytes and hepatoma cell lines to model the effects of fatty acids, fructose and glucose on liver cell lipid accumulation
Non-alcoholic fatty liver disease (NAFLD) begins with lipid accumulation within hepatocytes,
but the relative contributions of different macronutrients is still unclear. We investigated the …
but the relative contributions of different macronutrients is still unclear. We investigated the …
Liver organoids: updates on generation strategies and biomedical applications
S Liu, C Cheng, L Zhu, T Zhao, Z Wang, X Yi… - Stem Cell Research & …, 2024 - Springer
The liver is the most important metabolic organ in the body. While mouse models and cell
lines have further deepened our understanding of liver biology and related diseases, they …
lines have further deepened our understanding of liver biology and related diseases, they …