Single nucleotide polymorphisms (SNPs) that cluster in the first intron of fat mass and
obesity associated (FTO) gene are associated obesity traits in genome-wide association …

Mendelian randomization (MR) studies typically assess the pathogenic relevance of
environmental exposures or disease biomarkers, using genetic variants that instrument …

Until just a few years ago, the genetic determinants of obesity and metabolic syndrome were
largely unknown, with the exception of a few forms of monogenic extreme obesity. Since …

Genome-wide association studies (GWAS) have revolutionised the discovery of genes for
common traits and diseases, including obesity-related traits. In less then four years time, 52 …

Hydrogen sulfide (H 2 S) has profound biological effects within living organisms and is now
increasingly being considered alongside other gaseous signalling molecules, such as nitric …

Obesity rates have escalated to the point of a global pandemic with varying prevalence
across ethnic groups. These differences are partially explained by lifestyle factors in addition …

Obesity is an important factor contributing to the global burden of morbidity and mortality. By
identifying obesity susceptibility genes, scientists aim to elucidate some of its aetiology …

A central prediction of evolutionary theory is that energy invested into reproduction comes at
the expense of somatic maintenance and repair, accelerating biological aging. Supporting …

Evolutionary theory predicts that reproduction entails costs that detract from somatic
maintenance, accelerating biological aging. Despite support from studies in human and non …

Fibulin-3 (also known as EGF-containing fibulin extracellular matrix protein 1 (EFEMP1)) is a
secreted extracellular matrix glycoprotein, encoded by the EFEMP1 gene that belongs to the …