Placenta-on-a-chip: a novel platform to study the biology of the human placenta

JS Lee, R Romero, YM Han, HC Kim… - The Journal of …, 2016 - Taylor & Francis
Objective: Studying the biology of the human placenta represents a major experimental
challenge. Although conventional cell culture techniques have been used to study different …

Congenital Transmission of Trypanosoma cruzi: A Review About the Interactions Between the Parasite, the Placenta, the Maternal and the Fetal/Neonatal Immune …

U Kemmerling, A Osuna, AG Schijman… - Frontiers in …, 2019 - frontiersin.org
Chagas disease (CD), caused by the protozoan parasite Trypanosoma cruzi, is considered
a neglected tropical disease by the World Health Organization. Congenital transmission of …

A local innate immune response against Trypanosoma cruzi in the human placenta: the epithelial turnover of the trophoblast

A Liempi, C Castillo, I Carrillo, L Muñoz, D Droguett… - Microbial …, 2016 - Elsevier
Congenital Chagas disease, caused by Trypanosoma cruzi, is partially responsible for the
progressive globalization of Chagas disease despite of its low transmission rate. The …

Gene Expression Changes Induced by Trypanosoma cruzi Shed Microvesicles in Mammalian Host Cells: Relevance of tRNA‐Derived Halves

MR Garcia-Silva, F Cabrera-Cabrera… - BioMed research …, 2014 - Wiley Online Library
At present, noncoding small RNAs are recognized as key players in novel forms of
posttranscriptional gene regulation in most eukaryotes. However, canonical small RNA …

Host-parasite interaction: changes in human placental gene expression induced by Trypanosoma cruzi

C Castillo, I Carrillo, G Libisch, N Juiz, A Schijman… - Parasites & vectors, 2018 - Springer
Background Chagas disease is caused by Trypanosoma cruzi, a parasite endemic to Latin
America. Most infections occur in children by vector or congenital transmission …

Ex vivo infection of human placental chorionic villi explants with Trypanosoma cruzi and Toxoplasma gondii induces different Toll‐like receptor expression and …

C Castillo, L Muñoz, I Carrillo, A Liempi… - American Journal of …, 2017 - Wiley Online Library
Problem Trypanosoma cruzi and Toxoplasma gondii present, respectively, low and high
congenital transmission rates. The placenta as an immune regulatory organ expresses TLR …

[HTML][HTML] Microalgae extracts: Potential anti-Trypanosoma cruzi agents?

R Veas, M Rojas-Pirela, C Castillo, C Olea-Azar… - Biomedicine & …, 2020 - Elsevier
Introduction Chagas disease, caused by the protozoan parasiteTrypanosoma cruzi, has no
effective treatment available. On the other hand, microalgae are aquatic organisms that …

Ex Vivo Infection of Human Placental Explants by Trypanosoma cruzi Reveals a microRNA Profile Similar to That Seen in Trophoblast Differentiation

L Medina, JA Guerrero-Muñoz, AI Liempi, C Castillo… - Pathogens, 2022 - mdpi.com
Congenital Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is
responsible for 22.5% of new cases each year. However, placental transmission occurs in …

Pro‐inflammatory cytokines are modified during the multiplication of Trypanosoma cruzi within the placental chorionic villi and are associated with the level of …

E Benizio, MJ Moreira‐Espinoza… - American Journal of …, 2023 - Wiley Online Library
Abstract Problem Congenital Trypanosoma cruzi (T. cruzi) infection has been associated
with changes in the levels of TNF‐α and IFN‐γ during the pregnancy. Therefore, we propose …

Trypanosoma cruzi induces trophoblast differentiation: a potential local antiparasitic mechanism of the human placenta?

A Liempi, C Castillo, J Duaso, D Droguett, A Sandoval… - Placenta, 2014 - Elsevier
Introduction The congenital transmission of Trypanosoma cruzi (T. cruzi) is responsible for
one-third of new Chagas disease cases each year. During congenital transmission, the …