The lymphocytes, T, B, and NK cells, and a proportion of dendritic cells (DCs) have a
common developmental origin. Lymphocytes develop from hematopoietic stem cells via …

Abstract Cys2-His2 (C2H2) zinc finger domains (ZFs) were originally identified as DNA-
binding domains, and uncharacterized domains are typically assumed to function in DNA …

Chromosomal aberrations are a hallmark of acute lymphoblastic leukaemia (ALL) but alone
fail to induce leukaemia. To identify cooperating oncogenic lesions, we performed a genome …

A major challenge in systems neuroscience is to perform precise molecular genetic
analyses of a single neuronal population in the context of the complex mammalian brain …

During the last decades, many studies have investigated the transcriptional and epigenetic
regulation of lineage decision in the hematopoietic system. These efforts led to a model in …

While there has been significant progress in determining the transcriptional cascade
involved in terminal adipocyte differentiation, less is known about early events leading to …

Until recently, our understanding of the genetic factors contributing to the pathogenesis of
acute lymphoblastic leukemia (ALL) has relied on the detection of gross chromosomal …

Head and neck squamous cell carcinoma (HNSCC) is a very aggressive cancer. In
advanced stages, the patient has poor chances of receiving effective treatment, and survival …

Alterations in various developmental pathways are common themes in cancer. The early B-
cell factors (EBF) are a family of four highly conserved DNA-binding transcription factors with …

Runx2 is indispensable for osteoblast lineage commitment and early differentiation but also
blocks osteoblast maturation, thereby causing bone loss in Runx2 transgenic mice. Zinc …