Critical features of human addiction are increasingly being incorporated into complementary
animal models, including escalation of drug intake, punished drug seeking and taking …

Opioid use disorder (OUD) is a debilitating disorder that affects millions of people. Neutral
cues can acquire motivational properties when paired with the positive emotional effects of …

In the midst of the current coronavirus pandemic, the United States continues to struggle with
an ongoing opioid epidemic, initially fueled by widespread prescribing of opioid medications …

We recently developed a rat model of relapse to drug seeking after food choice-induced
voluntary abstinence. Here, we used this model to study the role of the orbitofrontal cortex …

Regulation of axonal dopamine release by local microcircuitry is at the hub of several
biological processes that govern the timing and magnitude of signaling events in reward …

Sex and gender deeply affect the subjective effects and pharmaco-toxicological responses
to drugs. Men are more likely than women to use almost all types of illicit drugs and to …

Background Opioid withdrawal is a key driver of opioid addiction and an obstacle to
recovery. However, withdrawal effects on opioid reinforcement and mesolimbic …

Rationale and objective Social factors play a critical role in drug addiction. We recently
showed that rats will abstain from methamphetamine, cocaine, heroin, and remifentanil self …

Rationale Opioid use disorder (OUD) is a major epidemic in the USA. Despite evidence
indicating that OUD may be particularly severe for women, preclinical models have yet to …

Fentanyl is a fully synthetic opioid with analgesic and anesthetic properties. It has become a
primary driver of the deadliest opioid crisis in the United States and elsewhere …